What drives inflammation-associated tumorigenesis and progression in pancreatic ductal adenocarcinoma (PDAC)? Doublecortin-like kinase 1 (DCLK1) is a central driver of inflammation-associated tumorigenesis, with elevated expression linked to worse clinical outcomes. Two isoforms of DCLK1 possess a unique extracellular domain (ECD). DCLK1 isoform 2 contains two microtubule-binding domains, while isoform 4, lacks the microtubule-binding domains but, plays a pivotal role in tumor progression. We...

BACKGROUND: Regional anesthesia (RA) is central to multimodal analgesia, yet many supporting randomized controlled trials (RCTs) may lack the rigor needed for evidence-based block selection.

Atomically dispersed metal atoms within graphitic carbon have shown great potential in enhancing the performance of lithium-sulfur batteries (LSBs), though the fundamental principles to guide their rational design remain to be fully established. Here, we report a combined computational and experimental study demonstrating that a group of metals (Ti, V, Mo, and Nb) incorporated into graphitic carbon have promising catalytic properties due to three factors: strong binding with lithium sulfides,...

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CONCLUSIONS: The incidence of AKI in recipients of pathogen-reduced red cells was noninferior to conventional red cell transfusion. Treatment-emergent antibodies were uncommon and not clinically significant.