Dermatophilaceae polyphosphate-accumulating organisms (PAOs), formerly classified as Tetrasphaera PAOs, play pivotal roles in enhanced biological phosphorus removal (EBPR). However, their phylogenetic diversity, ecological preferences, and metabolic traits remain poorly characterized, and a robust marker gene for their classification is lacking. Here, we performed an extensive phylogenomic and metabolic analysis of Dermatophilaceae PAOs utilizing 46 newly recovered metagenome-assembled genomes...

CONCLUSIONS: Social media support groups were acceptable to diverse young people and improved abstinence rates on average over 6 months compared to quitline referral.

Emerging evidence implicates opioid exposure in glial dysfunction and neuroimmune signaling. However, the role of oligodendrocytes in opioid-induced neuroinflammation remains poorly understood. Here, we demonstrate that oxycodone exposure upregulated high mobility group box 1 (HMGB1), a danger-associated molecular pattern (DAMP), in mature oligodendrocytes (OLs) but not oligodendrocyte precursor cells (OPCs). Oxycodone treatment significantly increased cytoplasmic translocation and extracellular...

Ras-associated autoimmune leukoproliferative disorder (RALD) is a rare, clonally derived leukoproliferative disorder that often affects the pediatric population and can show a variety of systemic, autoimmune symptoms. We describe an adult RALD patient clinically presenting with a lupus-like syndrome and demonstrating bone marrow and peripheral blood findings reminiscent of chronic myelomonocytic leukemia (CMML). This challenging presentation of a rare disease highlights the difficulty in...

A 35-year-old woman was initially diagnosed with classic dermatomyositis (DM) at age 21. We cared for her during 11 of those 14 years. Traditional immunosuppressive treatments did not control her DM skin disease activity. She was subsequently observed to have a juvenile-onset DM phenotype. For the past 11 years, her skin and muscle disease activity had been only partially controlled with monthly high-dose intravenous immunoglobulin (IVIG) therapy. During those 11 years of IVIG therapy, her skin...