Tumor treating fields (TTFields) therapy at 200 kHz is FDA-approved for supratentorial glioblastoma. However, reports of TTFields in patients with infratentorial high-grade glioma (HGG) are rare. Two patients with infratentorial HGG received off-label 200 kHz TTFields. To reduce impaired neck range of motion, the electrode transducer arrays were "skeletonized" by cutting a portion of the adhesive material. The electrode arrays were applied with the neck in flexion to further promote range of...

CONCLUSIONS: Endometriosis confers a slightly increased relative risk of specific ovarian cancer subtypes; however, the absolute risk remains low for most women, and this distinction is critical to avoid unnecessary anxiety, surveillance, or overtreatment. Individualized risk assessment and prospective studies integrating epidemiologic and molecular data are needed to refine stratification strategies and guide evidence-based care.

CONCLUSIONS: While overall CVD mortality in individuals with DM has improved, recent increases in AAMRs and persistent demographic and geographic disparities underscore the need for targeted public health strategies. Addressing these disparities is critical to sustaining progress and improving outcomes for vulnerable populations.

Embryonic livers undergo extensive vascular expansion after midgestation to support rapid growth and evolving functions. Immature embryonic vessels receive structural support from extracellular matrix (ECM), which is also essential for normal liver development and function. Meanwhile, pro-inflammatory cytokines that promote hematopoiesis and hepatic organogenesis must be tightly regulated to prevent sterile inflammation. However, endothelial contributions to ECM and cytokine production during...

Glioblastoma multiforme (GBM) is defined by rapid progression, high invasiveness, and a poor prognosis, with a median survival of only ≅13 months despite current treatments. Its marked genetic heterogeneity, high mutational burden, and cancer stem cell population make GBM exceptionally difficult to treat, highlighting the urgent need for more effective, multitargeted therapies. Non-coding RNAs, particularly tumor suppressor microRNAs (miRNAs), have gained attention for suppressing key oncogenic...