CONCLUSION: This review synthesizes previous work to increase understanding of the integration of dental health aides, through the CHAP Framework. Findings outline the key oral health workforce concepts to increase access to oral healthcare through a culturally adapted approach.

Systematic analysis of the fate of hydrogel nanoparticles after in vivo administration is essential for their clinical translation. Biodegradable, disulfide-crosslinked synthetic nanogels are a promising platform for the delivery of therapeutic molecules, but their biodistribution and clearance profiles remain underexplored compared to other solid nanoparticles. In this study, we investigated the safety, pharmacokinetics, tissue, and cellular distribution profiles of...

Nitrogen-related phosphotransferase (PTS^(Ntr)) systems are highly conserved and widely distributed in proteobacteria. These systems are thought to enable bacteria to sense and respond to changes in cellular carbon and nitrogen availability. The PTS^(Ntr) is analogous to the carbohydrate phosphotransferase systems that carry out phosphorylation and uptake of specific carbohydrates. Instead of targeting carbohydrates, the PTS^(Ntr) influences metabolic flux, virulence, biofilm development, stress...

Maternal obesity alters breast milk composition in ways that may predispose infants to excess adiposity. While maternal exercise during lactation has been associated with favorable shifts in milk metabolites in humans, the mechanisms by which exercise remodels the mammary gland and milk lipid profile to influence offspring metabolism remain unclear. We developed a mouse model incorporating daily moderate treadmill exercise only during lactation, using lean (LN) and diet-induced obese (OB) dams,...

The current range of African great apes includes countries with some of the world's highest incidence rates of human tuberculosis (TB). Non-human primates (NHPs) living in their natural habitats are expected to be free of TB. However, TB represents a known threat to captive NHP communities. We applied a non-invasive sponge-based environmental DNA (eDNA) sampling to run a cross-sectional survey at the human-animal interface in a challenging setting: the East of the Democratic Republic of Congo...