The prevalence of mitragynine, the major psychoactive component in kratom, has increased in forensic toxicology casework due to its current legal status and ease of accessibility in local shops and the online community. This study presents 28 death investigation cases from 2022 to 2023 in Oklahoma including mitragynine concentrations alongside case demographics, pathological findings, and additional toxicological results. Quantitative results for mitragynine in heart blood, femoral blood, and...

Estrogen receptor-positive breast cancer represents a significant proportion of breast cancer brain metastasis but remains understudied. Here we show that FGFR1-amplification, a well-established driver of estrogen receptor-positive breast cancer endocrine resistance, promotes estrogen receptor-positive breast cancer brain metastatic colonization in young and aged female mice, through both canonical FGF2/FGFR1 signaling and non-canonical NCAM1/FGFR1 interactions. Astrocytic FGF2-mediated...

CONCLUSIONS: While PWCF were bothered less by symptoms now compared to before starting ETI, some symptoms still caused a high degree of bother, particularly among 'older' adults with CF. Findings underscore the need for ongoing strategies to monitor and manage non-respiratory symptoms.

Intraplate intermediate-depth earthquakes (IDEs) occur at depths >70 kilometers, which is well below the brittle‒ductile transition in Earth's crust, and their origins are difficult to reconcile with traditional plate tectonics. We applied a deep-learning technique to regional seismic data and identified intraplate IDEs beneath Antarctica. Their occurrence can be explained by concentrated bending stresses resulting from variable, thermally driven uplift along the edge of East Antarctica, where...

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