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the Gateway to Research in Oklahoma

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Gateway to Research in Oklahoma


Oklahoma Shared Clinical and Translational Resources U54 GM104938

Researchers

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The GRO: Researcher Portal provides resources, information, and training to help individuals or communities involved in performing clinical and translational research in Oklahoma.

Providers

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The GRO: Provider Portal assists medical providers to identify clinical research opportunities in Oklahoma, tools for patient education, and evidence-based resources to improve patient care.

Patients

imgPatients

The GRO: Patient Portal can help patients and families to learn more about clinical and translational research and to connect with opportunities to participate in research opportunities in your communities.

Oklahoma Research Highlights

Cellular and molecular regulation of fibrotic post-operative abdominal adhesions

2 weeks 3 days ago
Abdominal adhesions are fibrotic bands of tissue that form following damage to the peritoneum, affecting the majority of abdominal surgery patients and resulting in an annual clinical burden exceeding $1.7 billion. Currently, adhesiolysis (surgical removal) is the only treatment available for adhesion-related complications but reoperation comes with a high risk of morbidity and increases the likelihood of future adhesion formation, requiring novel therapeutic approaches. While the mechanisms of...
Alexander J Mathewson

Impact of Father Involvement and Positive Parenting on Child Mental Health: Insights From a Survey of Ugandan Households

2 weeks 3 days ago
The influence of father positive parenting and involvement on children's mental health outcomes is underexplored in many sub-Saharan African countries, such as Uganda, despite research showing that fathers play a critical role in shaping their children's mental and emotional health outcomes. Most research on father involvement in parenting has been conducted in high-income countries in Western countries, and most research from Africa relies on mothers' reports. This study surveyed 236 Ugandan...
Ronald Asiimwe

The Relationship Between Language and Theory of Mind in Middle Childhood

2 weeks 3 days ago
This study examined the way in which language relates to theory of mind (ToM) during middle childhood. Two hundred and thirty-three children (ages 6-12) were tested via a concurrent design on vocabulary, phonological and morphological awareness, and six ToM domains (belief, knowledge, perception, desire, intention, and emotion). Results revealed that vocabulary had significant positive associations with three ToM domains (belief, knowledge, and intention), and morphological awareness, but not...
Ziqian Shen

Haploidentical versus matched unrelated donor transplantation with post-transplant cyclophosphamide: a platform-dependent machine learning analysis of donor age

2 weeks 3 days ago
In allogeneic hematopoietic cell transplantation with post-transplant cyclophosphamide (PTCy), clinicians frequently face a critical choice between a readily available, often younger, haploidentical and a fully matched unrelated donor (MUD). The platform-specific influence of donor age on survival is a critical, unquantified factor that complicates clinical decision-making. We retrospectively analyzed 4258 adult patients with acute leukemia who underwent first allogeneic HCT with PTCy...
Rohtesh S Mehta

Heritable variation drives rapid evolution of thermal performance curves in the protist Tetrahymena thermophila

2 weeks 3 days ago
Microbial respiration is a key biotic driver of climate change. Warming boosts microbial population growth, which increases biomass and respiration, potentially leading to more warming. This feedback might be disrupted by adaptation in thermal performance curves (TPCs) -whose shape describes how temperature drives growth. In this study, we uncover substantial genetic variation (G) in the intrinsic population growth rates (r) of the protist Tetrahymena thermophila, demonstrate a causal link...
Megan H Liu

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