BACKGROUND: This protocol outlines a systematic review with meta-analysis to evaluate the evidence that hearing aid use versus non-use enhances the health-related quality of life (HRQoL) of adults with sensorineural hearing loss (SNHL).

We previously demonstrated that vaccination with RSV-Mnull, a prototype single-cycle live vaccine lacking the matrix (M) gene, generated anti-viral serum IgG and memory T cell responses, and reduced challenge virus shedding and pulmonary dysfunction in mice. Here we further characterized the response to RSV-Mnull, and designed and tested second generation Mnull vaccines. In mice, prime-boost vaccination with RSV-Mnull generated pre-fusion (preF) and attachment protein (G) -specific serum IgG and...

We report correlative circulating tumor DNA (ctDNA) analyses from TRANSFORM (ClinicalTrials.gov identifier: NCT03575351) evaluating lisocabtagene maraleucel (liso-cel) versus standard of care (salvage immunochemotherapy, high-dose chemotherapy, autologous stem cell transplantation [ASCT]) in second-line large B-cell lymphoma (LBCL). ctDNA association with efficacy was investigated at predefined time points (random assignment, day 43, day 64, and day 126 [3 months after liso-cel, approximately 2...

CONCLUSIONS: Patients should be informed that RFMN may lead to dermal fibrosis, tissue adhesions, and altered superficial musculoaponeurotic system composition, which could interfere with future facelift procedures and the patient's desired treatment goals. This emphasizes the importance of detailed discussion between the patient and health care provider to improve pretreatment consultation, increase patient education, and set realistic expectations. Further research is needed to determine...

The hedgehog grain aphid (HGA), Sipha maydis Passerini (Hemiptera: Aphididae), is a significant pest of cereal crops and is present in the United States. Like other aphids, it exhibits wing polymorphism, producing both winged and apterous morphs influenced by environmental factors such as temperature and host plant quality. This study evaluated the effects of temperature and host plant species on life history traits and wing induction under controlled laboratory conditions. Two weeks after...