Water has strong directional interactions and forms a network of hydrogen bonds (H-bonds) in aqueous solutions. In order to assess the nature of this network as a function of the thermodynamic state, a generalized approach is introduced for enumerating the extended connectivity of H-bonding paths. By identifying and classifying rings formed from H-bonds where the donor-to-acceptor directionality can be considered, a ring summation factor metric can be constructed in a form comparable to the...

ObjectivesThis study investigates the relationship between universal design (UD) attributes, autonomy, and the psychological wellbeing of older adults with disabilities. The goal is to provide evidence-based design guide for aging-in-place, prioritizing UD elements that promote autonomy and psychological wellbeing.MethodA total of 165 older adults participated in the online survey. Using structural equation modeling, the latent factors of UD were identified for the kitchen, bathroom, and general...

Processing binaural cues is crucial for many acoustic communication tasks, and understanding the neural mechanisms of binaural sound processing gives important insights into how receivers localize signalers, which in anurans is a key component of mate selection. We characterized the binaural interaction component (BIC) of the auditory brainstem response (ABR) by collecting monaural and binaural ABRs using click stimuli with varying interaural time difference (ITD) and interaural level difference...

Triple Negative Breast Cancer (TNBC) is one of the most aggressive subtypes of breast cancer (BC), which is associated with a very poor prognosis. It is a broad category of tumors with a variety of biological, clinical, and morphological characteristics. FOXM1 is a pivotal transcription factor that modulates proliferation-associated genes through complex protein-DNA and protein-protein interactions, making it a highly attractive target in cancer therapy. However, existing small-molecule...

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