Robotic surgery has transformed urology. Simulation-based robotic training allows residents to develop skills in a controlled, risk-free environment and enhances proficiency. Our objective was to assess the integration of robotic simulation training in U.S. urology residency programs, focusing on adoption, curriculum types, mandatory status, and barriers to implementation. We distributed a Qualtrics survey to U.S. urology residency program directors to assess the presence and structure of...

The American Association of Colleges of Pharmacy (AACP) has long prioritized strategic engagement, recognizing the important role it plays in the fulfillment of institutional missions, the success of pharmacy education, the advancement of pharmacy and public health practice, and the meeting of programmatic needs. The 2024-2025 Strategic Engagement Committee (SEC) was charged to compile a catalog of best practices for state-level advocacy activities that leverage the influence of colleges of...

BackgroundCriticism of clinical trials of endovascular therapy of acute ischemic stroke due to large vessel occlusion includes their lack of generalizability. We aimed to evaluate the impact of vessel tortuosity on the outcomes of large-bore and super-bore aspiration catheters in the Imperative Trial and to compare trial's selection of patients to a real-world setting.MethodsUsing baseline craniocervical angiography, we performed semi-automated analysis of various tortuosity characteristics....

CRISPR base editors are crucial for precise genome manipulation. Existing APOBEC-based cytosine base editors (CBEs), while powerful, exhibit indels and sequence context limitations, and editing CC and GC motifs is challenging and inefficient. To address these challenges, existing tRNA adenine deaminase (TadA)-derived CBEs are evaluated in zebrafish, and a series of zTadCBE variants is developed that demonstrate high editing efficiency, minimized off-target effects, and an expanded targeting...

Mortalin is an essential chaperone for the import of nuclear-encoded proteins into mitochondria and is elevated in ovarian cancer in association with poor patient prognosis. The investigational new drug, SHetA2, interacts with mortalin releasing its client proteins. In this study, interactions of SHetA2 moieties and mortalin substrate binding domain (SBD) amino acids are demonstrated by surface plasmon resonance (SPR) and nuclear magnetic resonance (NMR) to occur at low micromolar SHetA2...