Electron transfer at a metal surface lies at the heart of most electrochemical processes, but the process is very challenging to model accurately with modern computational power. Here, we report an efficient algorithm for performing a dynamically weighted, state-averaged, constrained complete active space self-consistent field calculation with two electrons in two orbitals [DW-SA-cCASSCF(2,2)], an inexpensive algorithm that has the power to generate a balanced pair of charge-transfer-related...

CONCLUSION: The rising mortality rates from AF with cardiomyopathy in patients, particularly among men, Black individuals, and rural residents, demand urgent action. These concerning trends underscore a public health crisis that must be addressed.

CONCLUSIONS: Our findings highlight the importance of recognizing dual molecular diagnoses to untangle blended phenotypes, as well as the diagnostic relevance of synonymous variants with predicted splicing effects.

CONCLUSIONS: In this 52-week trial involving participants with active SLE who were receiving background therapy, the incidence of a clinical response was higher with telitacicept than with placebo. However, the incidence of upper respiratory infections, reduced immunoglobulin levels, and injection-site reactions was also higher with telitacicept. (Funded by RemeGen; 18C010 ClinicalTrials.gov number, NCT04082416.).

CONCLUSIONS: Early results of an ongoing phase I trial reveal that incorporation of patient navigation following initial radiation oncology consultation significantly improves adjuvant RT completion rates in early-stage black breast cancer patients. Further work examining patient navigation is ongoing.