During mammalian aging, there are changes in abundance of noncoding RNAs including microRNAs, long noncoding RNAs, and circular RNAs. Although global profiles of the human transcriptome and epitranscriptome during the aging process are available, the existence and function of mitochondrial circular RNAs originating from the mitochondrial genome are poorly studied. Here, we report profiles of circular RNAs annotated to mitochondrial chromosome, chrM, in young and old cohorts. The most abundant...

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A long-undeciphered script receives renewed attention and a contested interpretation.

PURPOSE: Neurocysticercosis (NCC) is a common cause of epilepsy in low- and middle-income countries (LMICs). Few studies have described neuroimaging findings in individuals with headaches in addition to epilepsy. Our aim was therefore to describe the types of NCC lesions seen on cerebral computed tomography (cCT), among participants with progressively worsening severe headaches (PWSH) and epilepsy living in 60 villages in Burkina Faso, and to determine the prevalence of NCC in these groups,.

CONCLUSIONS: This iAmHealthy multi-state feasibility RCT demonstrated high retention and successful blinding of assessors. Although the study was not powered to detect health outcome differences, iAmHealthy exhibited a tendency toward greater improvement or attenuated declines in child health outcomes, which supports the conduct of a future fully powered RCT.