CONCLUSION: Our results suggest that tailoring an exercise program to encourage activity on days when patients receive antineoplastic therapy, and to have the more intensive exercise days well after antineoplastic therapy, may be a good approach. Further research is needed to define interventions to improve physical activity in this population.

The human genome contains approximately 800 G protein-coupled receptors (GPCRs), all characterized by a common 7-transmembrane domain architecture. Here, we show that PKD1, an 11-transmembrane protein with a noncanonical transient receptor potential (TRP) channel architecture, functions as a GPCR with unique biochemical properties. PKD1 acts as a WNT-activated receptor, directly coupling to heterotrimeric Gα(i1-3) subunits to inhibit cellular cAMP accumulation. While PKD1 contains both...

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CONCLUSION: By broadening eligibility and streamlining logistics, PROSPECT-Lung reduces burden for patients, investigators, and sites while preserving scientific integrity. This pragmatic approach, when appropriate and possible, provides a replicable model for future cancer trials, promoting efficiency, accessibility, and real-world relevance.

This study examined the relationship between students' visual attention and their mathematical reasoning during video-based instruction. Applying a mixed methods contrasting case design, we investigated two undergraduate students' perceptual behaviors using the construct of attentive fidelity, which quantifies the alignment between viewers' gaze patterns and conceptually germane features of a video. We analyzed eye-tracking data to characterize each student's attentive patterns and conducted...