Free play, or self-directed play without adult prescription, may support neural and behavioral development during middle childhood; yet elementary-aged children have limited school-based play opportunities. This randomized crossover trial examined free play's effects on electroencephalography (EEG) and behavioral outcomes in 125 children (ages 5-12, grades 1-5) at a high-poverty urban school. Children were randomly assigned to receive 12 weeks of 45-minute weekly free play sessions in fall or...

CONCLUSIONS: Intervention feasibility and acceptability were demonstrated but require further refinement to achieve long-term, consistent glycemic control. Findings indicated that clinic staff workload and clinic workflow were key determinants of the study's feasibility and acceptability. Future research should test BALANCE in a fully powered randomized controlled trial to evaluate intervention effectiveness.

We undertook this study to elucidate the role of adipose progenitor cells (APCs) in governing sex differences in metabolic disease susceptibility and the heightened risk for metabolic disease in women after menopause. How do sex and estrogen influence APC differentiation capacity in subcutaneous adipose depots, and how does this relate to metabolic function in obesity? Estrogen mediates the recruitment of APCs for hyperplastic expansion of subcutaneous depots, which may contribute to...

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CONCLUSION: The hemostatic system in neonates and infants with congenital heart disease is distinct from that of older children and adults and warrants focused periprocedural evaluation and therapy. These recommendations guide understanding of the complex interactions during antithrombotic management in this patient population during cardiac surgical and catheter-based interventions.