It is widely accepted that tinnitus arises from maladaptive neuroplasticity in the central auditory system, which compensates for reduced peripheral input; notably, the loss of inner hair cell (IHC) synapses is considered a key underlying factor. IHC synapses can immediately and permanently degenerate after noise exposure, independent of hair cell loss, whereas the cell bodies and central projections of cochlear neurons can survive for months to years, providing an extended therapeutic window...

[This corrects the article DOI: 10.1039/D5RA05774D.].

Quantifying and differentiating the structural characteristics of clathrate hydrates at the molecular level is crucial for understanding the properties that underpin hydrate-based technologies. While useful, current approaches lack sufficient resolution to discern, e.g., interfacial and dynamical structures. In this study, we present an algorithm based on Density-Based Spatial Clustering of Applications with Noise (DBSCAN) that accurately identifies different water states coexisting within...

Adverse childhood experiences (ACEs) may predict markers of neurocognitive performance (i.e., executive function; EF) and brain health/plasticity (i.e., brain-derived neurotrophic factor; BDNF). This pilot examined: (1) ACES history and current EF performance, (2) ACEs history and current BDNF levels, and (3) current EF performance and BDNF levels. We hypothesized that higher ACEs would be associated with lower EF scores and that these patterns would be associated with serum BDNF levels. Given...

No abstract