Estrogens are pleiotropic hormones that regulate reproductive and non-reproductive physiological processes in both sexes. Among these, 17α-estradiol (17α-E2), a C17 epimer of the canonical estrogen 17β-estradiol (17β-E2), has emerged as a promising modulator of aging and metabolism with sexual dimorphism. Unlike 17β-E2, which exerts broad estrogenic effects in both sexes, 17α-E2 extends lifespan and preferentially improves metabolic homeostasis in male mice while inducing only mild feminizing...

CONCLUSIONS: Notwithstanding current regulatory frameworks, AE documentation for psoriasis trials remains fragmented with substantial inconsistency between registry and published data. These shortcomings undermine rigorous safety assessment and evidence-based clinical recommendations. Improved patient care requires increased integration of registry data into evidence synthesis, better clarification of AE definitions, and standardized AE reporting practices.

INTRODUCTION: Vaping-related content is prevalent on social media, including industry-sponsored advertising and user-generated content that normalizes use. While previous research suggests a link between social media exposure and vaping, this relationship remains understudied among vulnerable populations like Mexican Americans. This study examined the relationship between daily social media exposure and vaping among Mexican American young adults.

CRISPR-Cas systems comprise a CRISPR RNA (crRNA)-guided CRISPR-associated (Cas) nuclease for providing immune protection. The complementary base pairing between crRNA and the invader genome leads to the formation of an "R-loop", which triggers the nuclease activity of the Cas protein, effectively neutralizing the invasion. This molecular mechanism has been repurposed for genome applications using Cas9 and Cas12a. Cas12a has several favorable features for applications including its smaller size,...

CONCLUSION: Multi-omic analysis of the NRG/RTOG-0539 cohort shows that updated WHO grading criteria, incorporating molecular and cytogenetic features, improve risk stratification. However, molecular classification, particularly the Proliferative group, remains an independent and stronger predictor of RT response. These findings support integrating molecular biomarkers alongside modern grading frameworks to guide treatment and trial design in meningioma.