Trace minerals are essential for animal health but can also, together with heavy metals, have a negative impact, making their monitoring crucial to assess animal health. These elements were examined through a long-term post-mortem monitoring system based on routine liver sampling for Heck cattle, Konik horses and red deer in place at the Oostvaardersplassen nature reserve in the Netherlands, using data from this system to determine reference intervals and investigate trends in liver trace...

Managing biological invasions is one of the top priorities of biodiversity conservation. Invasive plants are a well-known threat to native plant and animal communities, and understanding their ecological impacts is critical to developing individualized management strategies. While much is known about the impacts of invasive plants, there are still questions about the per capita effects along invasion abundance gradients across levels of biological organization. In this study we investigate how...

The European corn borer (Ostrinia nubilalis) is a major lepidopteran pest, causing annual maize losses of 5.5-8.5 million tons worldwide. Successful mating relies on the male's ability to detect species-specific, hydrophobic sex pheromones released by females. Pheromone-binding proteins (PBPs), abundantly expressed in male antennae, capture these pheromones and transport them through the sensillar lymph to olfactory receptor neurons. Here, we report the first successful heterologous expression,...

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The basal-like molecular subtype of pancreatic ductal adenocarcinoma (PDAC) is highly lethal and therapy resistant. A better understanding of the underlying molecular mechanisms driving this aggressive tumor subtype is necessary for the development of effective therapies. Notably, upregulation of keratin 17 (K17) in cancer is associated with poor patient outcome and the basal-like PDAC subtype. Here, we identified a critical dependency of basal-like PDACs on de novo pyrimidine biosynthesis,...