Dengue fever remains a growing public health threat in Bangladesh, with urbanization, temperature variability, and limited healthcare resources exacerbating recurrent outbreaks. Although many studies have modeled dengue dynamics, the explicit role of treatment under temperature variability remains poorly quantified. Here, we present a simple and interpretable Susceptible-Infected-Treated-Recovered-Susceptible (SITRS) model for humans, coupled with a mosquito Susceptible-Infected (SI) model...

Bronchopulmonary dysplasia (BPD) is the most common respiratory disease in preterm infants born at less than 28 weeks gestation. Most existing clinical prediction models for BPD show limited accuracy in predicting BPD development when validated using external data, stressing the need for novel biomarkers to identify at-risk infants for early and effective interventions. We leveraged existing frozen umbilical cord blood samples from the Northwestern University Cord Blood Biobank (NUCord) to...

Bioconversion of CO(2) into liquid fuels represents a promising strategy for advancing carbon-neutral biomanufacturing. Clostridium muellerianum (P21), a recently identified acetogen, has demonstrated the capability to convert CO(2) into C2-C6 alcohols. However, the process parameters affecting product distribution and chain elongation remain uncharacterized. This study evaluated the effects of medium composition, temperature, headspace pressure, and CO supplementation on CO(2) fermentation by...

Collective motion in biological swarms emerges from local interactions among individuals with limited sensing and cognition, offering valuable insights for decentralized engineered systems. This study presents a systematic framework for extracting interaction graphs from multiagent trajectory data. Three graph identification methods, sparse regression, Granger causality, and cross-correlation, together with geometric anisotropy analysis, are applied to experimental recordings of honey bees...

Photoreceptors rely on efficient clearance of outer segment material and mislocalized proteins to maintain cellular health and visual function. While retinal pigment epithelial (RPE) cells remove shed outer segment tips through daily phagocytosis, the mechanisms by which photoreceptors eliminate misfolded or mistargeted proteins are not well understood. Here, we identify PIKfyve, a lipid kinase that synthesizes phosphatidylinositol 3,5-bisphosphate [PI(3,5)P₂], as a key regulator of degradative...