CONCLUSIONS: The addition of trastuzumab to CRT for localized HER2+ EAC did not improve PROs.

Gymnosperms, particularly conifers, exhibit a high abundance of transposable elements (TEs) in their giga-scale genomes. TEs interact antagonistically and cooperatively with the host genome, promoting structural and genetic innovations across evolutionary lineages. How TEs are involved in shaping the coding space of gymnosperm genomes is one remaining key question. Herein, we generate the high-quality genome assembly for a keystone conifer, Platycladus orientalis, with a contig N50 of 57.54 Mb...

Peptides are desirable therapeutics due to their inherent potency, safety, and ability to engage complex protein surfaces. Slower kinetics of protein-peptide (un)binding can directly influence their drug efficacy and duration of action, in part by improving plasma stability of the peptide. A better understanding of peptide binding mechanisms would benefit for the development of next-generation peptide-based drugs with optimized kinetic properties. The calcitonin receptor-like receptor:receptor...

Kollock, RO, Hale, WD, Fulk, M, Sullivan, C, Thomas, J, Sanders, G, and Peveler, W. The impact of load per kilogram of body mass carried on dynamic postural stability in firefighter cadets. J Strength Cond Res 39(9): e1105-e1111, 2025-Slips, trips, and falls continue to be one of the leading causes of injury on the fireground. The load per kilogram (kg) of body mass carried (LpBM) in equipment and gear (EQG) by firefighters may contribute to fall susceptibility. The primary purpose of this study...

Preparing nursing students for emotional challenges before entering the nursing profession is essential. This study highlights the lack of nursing students' emotional regulation skill growth in nursing programs in a south-central region of the United States and highlights the need to assist students in developing adaptive emotional regulation skills before entering the nursing profession to prevent negative outcomes. Strategies to assist in the development of skills are presented.