Ceftazidime-avibactam (CAZ-AVI) is a crucial treatment for multidrug-resistant (MDR) gram-negative infections; however, the impact of treatment timing and outcomes in real-world practice remains unclear. This study evaluated CAZ-AVI use across diverse U.S. centers, with emphasis on early initiation. We conducted a retrospective cohort study at 22 U.S. medical centers (2019-2025), including adults with MDR gram-negative infections who received CAZ-AVI ≥ 72 h. The primary outcome was composite...

CONCLUSION: In this large real-world cohort of patients with HCM and AF, catheter ablation was associated with lower mortality, reduced HF hospitalizations, and decreased AAD therapy-related adverse events, as compared with medical therapy. These findings suggest that catheter ablation may provide meaningful clinical benefits in selected patients with HCM and AF, although prospective studies are needed to confirm these observations.

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INTRODUCTION: Volunteerism in midlife and later life is linked to improved well-being for individuals and stronger communities, but participation rates differ widely across groups. Most existing research has focused on socioeconomic factors to explain volunteering, while cultural factors have received less attention and are often narrowly defined, usually in terms of religiosity. As a result, it remains unclear how culture is conceptualized and examined in relation to volunteering in later life....