CONCLUSION: The combination of bortezomib with clofarabine demonstrated limited antitumor effects possibly due to the inability to reach the efficacious doses achieved in preclinical models.

A variety of techniques exist for the reconstruction of skull base defects. However, the gold standard for skull base reconstruction is vascularized flaps, especially when there is a cerebrospinal fluid leak. The most frequently used flap is the nasoseptal flap, which has numerous applications, has relatively low morbidity, and is straightforward to harvest. When this flap is unavailable, other options include the inferior turbinate flap, middle turbinate flap, lateral wall flap, pericranial...

Vascular cognitive impairment and dementia (VCID) is increasingly recognized as one of the leading causes of cognitive decline in aging populations. VCID is driven by the interplay of endothelial dysfunction, chronic inflammation, oxidative stress, and metabolic dysregulation. Aging exacerbates cerebrovascular damage by impairing endothelial function, compromising the blood-brain barrier (BBB), and promoting neuroinflammation, all of which contribute to the progression of small vessel disease...

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Epidemiological studies consistently link higher fish intake with slower rates of cognitive decline and lower dementia incidence. The aim of the present study was to systematically review existing observational studies investigating the association between fish consumption and cognitive function in older adults. A total of 25 studies (8 cross-sectional and 17 prospective including mainly healthy older adults, age range of participants ranging from 18 to 30 years at baseline in prospective...