CONCLUSIONS: Significant bilateral BCHD benefit was noted for roving speech in diffuse noise, similar to group conversations in noisy restaurants. Significant benefits were not observed for a fixed sound source in colocated noise making clinical assessment of the potential benefit of a second BCHD challenging; however, performance in the bilateral BCHD condition was either similar to or better than the best single ear alone thereby consistent with clinical benefits observed in complex noise....

CONCLUSIONS: A trial of selective early PDA pharmacotherapy based on clinical and echocardiography grading of PDA shunt volume in the smallest infants is feasible with minimal protocol deviation. Early echocardiography screening and selective pharmacotherapy using the SMART-PDA algorithm may enhance the probability of survival with less morbidities in infants born <26 weeks GA.

CONCLUSION: Most infections in pwMS are first reported by non-neurology providers, as most pwMS did not interact with their MS clinician in the first few months after infection, even if that infection was severe. These data highlight the importance of communication between different providers and patients to accurately assess patient status and DMT safety, leading to improved patient outcomes.

Eukaryotic cells license far more potential replication origins than they use, but how origin firing rate is tuned in S phase, especially under replication stress, remains unclear. Here, we identify a regulatory mechanism by which cyclin-dependent kinase (CDK) activity controls the abundance and chromatin recruitment of the origin firing factors TRESLIN and MTBP to promote dormant origin activation. Inhibition of WEE1 kinase during S phase increases CDK activity, which blocks the...

Cognitive abilities may allow flexible responses to variable environments, proving critical to individual survival in many species. When cognitive abilities are associated with survival, we may also expect cognition to be under sexual selection, as mate choice based on cognitive traits can lead to increased fitness. However, evidence for whether and how individuals assess the cognitive abilities of conspecifics is variable and sparse. We investigated whether individual variation in heritable...