Hagfishes are representatives of the phylogenetically important, early-branching vertebrate lineage Agnatha, and many endocrine signaling systems in this group remain poorly understood. In this study, we provide the first molecular and functional characterization of melanocortin receptors (Mcrs) and their accessory protein (Mrap) in hagfishes. Using genomic and transcriptomic resources from inshore hagfish (Eptatretus burgeri), Pacific hagfish (Eptatretus stoutii), and Atlantic hagfish (Myxine...

CONCLUSION: Patients in phase 2 cancer trials commit a substantial amount of time to research participation. Further work is needed to compare these estimates to time spent in standard of care, and to find ways to reduce the time toxicity of trial participation.

Parental psychological distress and children’s internalizing and externalizing behavioral problems could co-occur rather than operate independently, yet it remains unclear whether the likelihood of such co-occurrence varies by levels of food insecurity. By examining these co-occurring challenges in the context of food insecurity, this study aims to clarify the extent to which the alleviation of food insecurity could reduce the co-occurrence of parental psychological distress and child...

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CONCLUSION: Findings elucidate associations of discrimination (for female SGM adults) and time spent in SGM spaces (for male SGM adults) with more relaxation/tension-reduction cannabis use motives and associations of relaxation/tension-reduction use motives with worse cannabis use outcomes. Findings provide preliminary insights into the potential need for community-level interventions aimed at reducing discrimination and individual-level interventions aimed at promoting healthier coping...