Fluorine has been widely incorporated into small-molecule drugs as an effective strategy to modulate metabolic stability, lipophilicity, target interactions, and overall pharmacokinetic profile. As a result, fluorine-containing compounds remain well represented among newly approved therapeutics across a broad spectrum of disease areas; notably, in 2025, 14 of the 29 small-molecule drugs approved by the U.S. Food and Drug Administration (FDA) contained at least one fluorine atom, underscoring the...

Existing empirical research examining PTSD related to disaster exposure has generally been limited to quantitative methods and also cross-sectional rather than over time. The purpose of this qualitative study was to retrospectively examine postdisaster emotions emerging over time in highly trauma-exposed disaster survivors, comparing individuals with and without PTSD. Survivors of the 1995 Oklahoma City bombing were interviewed approximately 17 months after the bombing, assessed for PTSD, and...

Theories of chronic nightmare maintenance highlight dysfunctional beliefs about sleep and nightmares, distress and arousal, anticipatory anxiety, maladaptive sleep habits, and sleep deprivation as perpetuating factors that maintain nightmare disorder over time. Theories of nightmare treatment suggest that self-efficacy is a common factor in nightmare mitigation. The current article introduces DARC-NESS, a multi-component theory of nightmare maintenance that emphasizes nightmare self-efficacy as...

The proliferation of digital health technologies has transformed healthcare delivery globally. Within this context, online patient-provider communication (OPPC) has emerged as a significant tool for facilitating patient-provider interactions. Using data from Brazil (N = 1,099, M(age) = 37.83) and Portugal (N = 1,011, M(age) = 40.79), this comparative study explored discrepancies in OPPC utilization and related outcomes by examining the relationship between OPPC and healthcare satisfaction....

Azithromycin is a widely used antibiotic and was frequently used to treat hospitalized patients during the COVID-19 pandemic. The impact of empiric azithromycin use on the respiratory microbiome in patients with viral respiratory infections is unclear. Here we used longitudinal metatranscriptomics on nasal swabs from a prospective multicentre cohort of 1,164 patients hospitalized for COVID-19. We compared the upper respiratory microbiome, resistome and systemic immune response in patients...