Indole-tetrahydroazepine derivatives of iboga alkaloids (ibogalogs) exhibit antidepressant, anxiolytic, promnesic, and antineuropathic effects, mainly via serotonergic targets. However, their physicochemical properties relevant to redox biology, including antioxidant activity and membrane stability, have remained poorly characterized. We investigated the antioxidant properties of three ibogalogs: ibogaminalog (DM506), ibogainalog (IBG), and tabernanthalog (TBG), using model lipid membranes...

CONCLUSIONS: Tibial osteotomy of the MCL insertion provided significantly improved visualization of the medial tibial plateau compared to MCL split technique and achieves similar exposure to femoral epicondyle osteotomy, while preserving the soft tissue structures proximal to the meniscus.

To broaden understanding of breast cancer pathophysiology, we investigated the highly understudied DNPH1 enzyme in this disease. We found that DNPH1 is overexpressed in breast and also in prostate and lung tumors, correlating with disease aggressiveness. DNPH1 downregulation diminished the oncogenic potential of breast cancer cells and compromised respective stem cells. Likewise, DNPH1 ablation decreased the oncogenicity of lung cancer cells. Knockout of Dnph1 in mice revealed that DNPH1 is not...

CONCLUSION: Although PROSPERO remains the reference registry, INPLASY and OSF are playing an increasingly important role in promoting openness and accessibility. Researchers are encouraged to search multiple registries, especially PROSPERO, INPLASY, and OSF, before starting a new study to minimize the duplication of efforts.

Transition readiness interventions support the health and independence of adolescents and young adults (AYAs) with type 1 diabetes (T1D) as they move from pediatric to adult healthcare. A theoretical model of transition readiness emphasizes the importance of family and culture in AYA disease management. Yet, it remains unclear how family and culture are currently incorporated into T1D transition readiness interventions and how such factors may support AYAs during this transition. This mini...