Vascular access for endovascular procedures can be challenging in pediatric patients with congenital heart disease. We present two patients in which a left mini-thoracotomy was utilized to access the descending aorta for endovascular aortic stenting. The first patient was a 5-year-old male who had undergone a Fontan pathway and developed a significant stenosis of the distal arch. The second patient was a 10-month-old born with a coarctation who developed recurrent stenosis and a pseudoaneurysm...

The effect of mitochondrial-haplotype (mt-haplotype) on aging was studied using a unique rat model (OKC-HET^(B/W)), which has a heterogenous nuclear background combined with mitochondria from either Brown Norway (B-haplotype) or Wistar Kyoto (W-haplotype) rats that differ in 94 nucleotides. The impact of mt-haplotype on aging was studied using an unbiased multi-omics approach to analyze the plasma from 9- and 26-month-old male and female OKC-HET^(B/W) rats. Of the 280 metabolites, 961 lipids,...

Natural products are a rich source of bioactive molecules and undiscovered chemical scaffolds with significant potential for drug discovery. Among producers of natural products, fungi are particularly promising, offering diverse metabolites and undiscovered structural motifs. Large, well-curated collections of crude extracts, or "libraries", are central to fungal natural product discovery, serving as starting material for bioassay-guided isolation of new compounds. However, the systematic...

CONCLUSIONS: Children with non-syndromic congenital anomalies are at increased risk of sarcomas, especially soft tissue sarcomas. Future studies should clarify shared developmental pathways and evaluate implications for sarcoma risk prediction and surveillance.

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