Photoredox catalysis is widely considered as a more sustainable alternative for performing chemical synthesis, using low-energy visible-light photons as traceless reagents to achieve the desired reactivity under mild conditions. While this has led to significant improvements in sustainability for many transformations, the environmental impact of the photocatalysts themselves is often overlooked, with many methods relying on precious metals with uncertain long-term availability. One solution that...

Nitric oxide (NO) insertion into a metalloporphyrin rhodium-carbon bond is observed when crystals of (TPP)-Rh-(C(6)H(4)Cl)-(CH(2)Cl(2)) (x) (TPP = tetraphenylporphyrinato dianion) are exposed to NO gas over a two week period. The NO-inserted product was identified by X-ray crystallography as (TPP)-Rh-(ONC(6)H(4)Cl-o)-(CH(2)Cl(2))(0.5)·(TPP)-Rh-(C(6)H(4)Cl-p/m)-(CH(2)Cl(2))(0.5), in which NO inserted selectively into the ortho-Cl aryl isomer but not into the para-/meta-Cl aryl isomers. Density...

Social interactions encompass complex behaviors that promote individual and group benefits such as communication and cooperation but can also include negative outcomes including competition and conflict. Neural circuits that facilitate social behaviors begin developing in utero and are informed by the maternal environment which include nutritional status, immune state, stress, and microbiome composition. This relationship between the maternal environment during pregnancy and the programming of...

Purpose Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal and aggressive malignancies with limited treatment options. Curative surgical resection of the primary pancreatic mass is frequently limited by residual microscopic tumor foci, leading to a high recurrence rate in patients. To improve surgical outcomes, visualizing remaining tumor foci with fluorescent probes is crucial to achieve complete (R0) resection. Methods A peptide-based imaging probe targeting the angiotensin...

CONCLUSION: Skin malignant neoplasm mortality in the United States shows an overall declining trend, but significant disparities exist across demographic characteristics and geographic regions. These findings provide important evidence for developing targeted prevention strategies and resource allocation for high-risk populations. Future research should further explore potential factors behind these disparities, including socioeconomic factors, healthcare accessibility, and environmental...