CONCLUSION: In this pilot RCT, we demonstrated high engagement and acceptability of a novel supportive care intervention for patients with LARC. Study results will guide refinements to the PATHWAYS intervention and future study procedures.

Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, largely due to aggressive tumor behavior, immune evasion, and limited responsiveness to immunotherapy. Circular RNAs (circRNAs) have emerged as important regulators of cancer progression; however, the roles of exosomal circRNAs in tumor-immune communication in GC remain poorly understood. Here, circRNA profiling of exosomes derived from GC tissues and matched adjacent normal tissues identified circFXR1 as an...

This study presents an overview of official elder abuse data for US states and is the first to assess county-level predictors of elder abuse and neglect through the lens of social disorganization theory. Five years of official elder abuse and neglect, violent crime, and property crime data from three midwestern states, Illinois, Kansas, and Missouri, were aggregated and studied to determine whether the same factors that predict violent and property crime are useful for understanding variation in...

CONCLUSIONS: While spatiotemporal stepping measures were similar between groups, PwMS demonstrated distinct compensatory stepping strategies compared to healthy controls. These findings highlight the need for targeted interventions aimed at improving lateral balance reactions and reducing fall risk in PwMS.

Given the high rate of sexual victimization committed by youth, it is critical to identify the etiological pathways of intrusive sexual behavior (ISB) to prevent future acts. ISBs are sexual behaviors that are aggressive, forceful, or otherwise coercive. Previous research has suggested that child maltreatment experiences are key environmental risk factors for ISB. The specific mechanism requires further study, including the potential pathway of subsequent posttraumatic symptom clusters (PTSS)...