Colorectal cancer (CRC) remains a leading cause of cancer mortality globally, yet current histopathological diagnostics capture only limited features. This study aimed to discover subtle, prognostically significant histomorphological patterns in CRC tissues using unsupervised deep learning. We developed a framework integrating convolutional neural networks with deep clustering, trained on 23,341 image patches from 493 patients. We identified 30 distinct histomorphological clusters from CRC...

Chinese Americans who smoke have low use of nicotine replacement therapy (NRT). This study explored perceptions of NRT and decision-making around product choice among Chinese American smokers who received NRT. From September 2023 to January 2024, we conducted in-depth phone interviews with 20 participants recruited in New York City from a WeChat-based cessation pilot trial and a community-based cessation program, both providing free nicotine patches, gum, or lozenges. Participants (aged 26-72;...

Psocids are difficult to manage using insecticides, hence the need for alternatives including biological control. Evaluation of data from two separate studies was conducted. One study investigated the potential of Cheyletus eruditus (Shrank) (Trombidiformes: Cheyletidae) and Cheyletus malaccensis Oudemans to manage Liposcelis decolor (Pearman) (Psocodea: Liposcelididae), whereas the other investigated the potential of Xylocoris flavipes (Reuter) (Hemiptera: Anthocoridae) to do the same....

Bladder cancer (BCa) is the second most common cancer of the genitourinary tract globally. It has limited treatment options, high recurrence rate, and acquires resistance to platinum-based therapy. Therefore, identifying novel therapeutic targets is urgently needed. Analysis of the TCGA data revealed that the enzyme galactokinase-1 (GALK1) is overexpressed (p < 0.0001) in bladder tumors compared to normal tissue. Our data also confirmed GALK1 protein upregulation in multiple human BCa cell lines...

Gun violence in U.S. schools continues to be a persistent concern. A promising line of scholarship focuses on potential school gun attacks that were stopped before they could occur, but this work is limited to a small number of studies. This study investigates how potential school gun attacks were exposed by analyzing 124 publicly reported cases from 2018 to 2023. For the analysis, we generated descriptive data on the school contexts, individuals, and processes associated with exposing potential...