Household air pollution (HAP), particularly from cooking-related particulate matter (PM(2.5)), poses significant health risks but remains understudied compared to ambient air pollution. We evaluated the short-term cardiorespiratory effects of exposure to cooking-generated PM(2.5) and examined the efficacy of automated indoor air quality interventions. Using a crossover design, seven cohorts of two participants each were exposed to two residential conditions over four weeks in a Living Lab: the...

CONCLUSIONS: Adherence to the global CTO crossing algorithm is associated with greater crossing success using the initially selected strategy, higher technical success, and similar in-hospital MACE.

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Biological sex differences in morbidity upon influenza A virus (IAV) infection are linked to stronger IFN-centered immune responses in females, yet the regulatory role of sex steroid receptors in immune cell subsets is incompletely understood. Lung-resident group 2 innate lymphoid cells (ILC2s) express notably high levels of androgen receptors (AR). In IAV infection, ILC2s produce type 2 cytokines and facilitate tissue repair, but they also may be functionally suppressed by type 1 cytokines....

Early-life airway epithelial development relies on tightly coordinated mitochondrial metabolic programs, yet the pathways that govern normal epithelial maturation during this vulnerable developmental window remain poorly defined. Hyperoxia disrupts airway epithelial maturation, contributing to lung injury and airway remodeling in infants with bronchopulmonary dysplasia (BPD), underscoring the need to identify mitochondrial pathways that regulate early epithelial differentiation....