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CONCLUSIONS AND CLINICAL RELEVANCE: This study highlights the psychological factors in owner persistence with ASIT. HBM-informed educational strategies that emphasise disease impact, treatment value and owner confidence may improve persistence with ASIT and long-term disease management.

CONCLUSION: While exploring the impacts of ETI therapy on pancreatic function, this study revealed a potential reversal of pancreatic insufficiency. The results suggest the importance of early initiation of therapy and standardized protocols to monitor FE-1 values over time.

CONCLUSIONS: High-quality data on anticoagulant prophylaxis for pediatric VTE prevention are scarce. Key research priorities include the development and validation of subgroups-specific VTE risk assessment models, and evaluation of the safety and efficacy of risk-stratified anticoagulant prophylaxis strategies across different pediatric subgroups.

Radiotherapy (RT) is a mainstay in the treatment of solid tumors, including lung cancer, yet the long-term efficacy is often limited by radioresistance. RT promotes multiple different cell death processes, and gaining mechanistic insights into how metabolic cell death pathways like ferroptosis contribute to resistance could enable the development of effective modulators of radiation sensitivity. Here, through metabolomic and functional analyses, we identified dihydroorotate dehydrogenase (DHODH)...