CONCLUSIONS: Cohort life expectancy estimates across US states over the birth cohorts born between 1941 and 2000 have shown important gains in all states and regions. The lack of progress estimated in other work is not replicated; for example, recent work estimated that between 1950 and 2000, at least 15 states' female populations experienced cohort life expectancy losses; however, the use of better data and robust methods show no losses by any state. Our results also point to early life public...

CONCLUSION: Our findings show the high burden of symptomatic enteric viral infections, particularly norovirus, as well as the high frequency of asymptomatic infections, thereby improving our understanding of the epidemiology and clinical manifestations of enteric viral infections in young US children.

Significant genetic heterogeneity has hindered the identification of molecular targets and development of effective targeted therapies for triple negative breast cancer. Currently available targeted therapies are not curative for TNBC patients. Eukaryotic Elongation Factor-2 kinase (eEF2K) is a clinically significant proto-oncogenic therapeutic target linking this atypical alpha kinase to poor patient survival and a key driver of tumor growth and progression in TNBC, positioning it as a critical...

CONCLUSION: Perioperative nutritional optimization, including vitamin D repletion, vitamin C, magnesium support, MPFF therapy, and structured EAA supplementation, represents a safe, accessible, and evidence-supported strategy to enhance recovery after TJA. Integrating targeted nutrition into prehabilitation pathways may help reduce complications and support faster functional gains.

The integrity of the blood-retinal barrier remains largely unexplored in glaucoma. Here we show that elevated intraocular pressure partially compromises the blood-retinal barrier in three distinct mouse models of glaucoma. This compromise induces subtle leakage without bleeding or detectable disruption of endothelial cell junctions and precedes neurodegeneration. Leakage occurs from peripheral veins in the retinal ganglion cell layer with a concomitant loss of the transcytosis inhibitor MFSD2A....