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CONCLUSIONS: This study is the first to compare baseline participant characteristics by recruitment method (in person vs online) in a cessation RCT for people experiencing food insecurity and to evaluate the relative pace of recruitment via those methods. Online and in-person recruits were demographically and psychosocially distinct, and online recruitment was associated with faster accrual than in-person recruitment. These findings inform recruitment strategies for cessation interventions,...

CONCLUSION: CRC clinical trials in the United States predominantly over-represented White populations while under-representing Asian, Black, and Hispanic populations. These findings highlight the need for more equitable representation in clinical trials to ensure that diverse populations benefit from medical research advancements.

While linear mixed-effects (LME) models are common for analyzing longitudinal data, most users rely on random intercepts or simple stationary covariance, due to unavailability of computationally tractable solutions. Here, we extend the Fast and Efficient Mixed-Effects Algorithm (FEMA) and present FEMA-Long, a computationally tractable approach to flexibly modeling longitudinal covariance suitable for high-dimensional data. FEMA-Long can: i) model unstructured covariance, ii) model covariates as...

It has been known for over 80 years that bacterial cell size is affected by growth conditions. Cells grown in nutrient rich medium are larger and wider than those grown in nutrient poor medium. Yet even after decades of research it is still not fully known how metabolism and cell size are coregulated. In this work, we describe a new source of metabolic control over Escherichia coli cell size, the phosphoenolpyruvate phosphotransferase system (PTS). The PTS is used to phosphorylate sugars upon...