In Pseudomonas aeruginosa, bacterioferritin contributes to regulating cytosolic iron by oxidizing Fe^(2+) and storing Fe^(3+) within its internal cavity, and binding to its cognate ferredoxin to reduce stored Fe^(3+) and release Fe^(2+) to the cytosol. Small molecule derivatives of 4-aminoisoindoline-1,3-dione bind P. aeruginosa bacterioferritin at the cognate ferredoxin binding site, inhibit iron release from bacterioferritin, and exhibit bactericidal activity against mature P. aeruginosa...

Emergency management higher education is a critical component of the emergency management enterprise. Since the first degree programs began in the 1980s, significant efforts have been undertaken to develop emergency management higher education to meet the growing and changing needs of practice. These efforts have historically been supported by the Federal Emergency Management Agency (FEMA), specifically the FEMA Higher-Education Program. Recent changes at FEMA have called into question how the...

Pseudomonas aeruginosa (Pa), a ubiquitous opportunistic pathogen, is notorious for causing diverse life-threatening infections, including lethal lung infections in patients suffering from cystic fibrosis (CF). Pa's ability to adapt to various environments is largely attributed to its metabolic flexibility and extensive regulatory networks. Understanding the mechanisms driving Pa adaptation during colonization of the airways of CF patients is of critical clinical importance. Previous studies by...

Donation after circulatory death (DCD) livers increasingly use machine perfusion (MP). This study evaluates MP's impact on older DCD livers based on data from the United Network for Data Sharing, covering all first adult DCD liver transplants (2016-2025). The cohort, divided into pre-MP and MP eras (separated by the FDA approval of the first normothermic MP platform in 2021), showed accelerated growth in DCD liver transplants during the MP era. Donors ≥60 rose 7.8-fold, including donors ≥70 (a...

Down syndrome regression disorder is a severe neuropsychiatric condition for which intravenous immunoglobulin offers partial benefit in many cases. The efficacy of second-line immunosuppressive therapies in those with partial responses to intravenous immunoglobulin (IVIg) remains unclear. This study sought to evaluate the comparative efficacy of B-cell depletion, Janus kinase inhibition, and mycophenolate mofetil as second-line immunosuppressive therapies in individuals with Down syndrome...