CONCLUSIONS: Inclusion of fish in a healthy and balanced diet is associated with better white matter grades on MRI and slower progression of white matter hyperintensities and reduction of vascular-related lesions of the aging brain, suggesting a potential role in preventing neurocognitive deterioration. Heterogeneity across studies underscores the need for additional studies.

CONCLUSIONS: We observed a sustained impact of maternal plus child SQ-LNS on growth and language development among female children, but not among males. Further research is needed to investigate mechanisms underlying the sex difference in response to nutrient supplementation in early life. The trial in Ghana was registered as NCT00970866 on September 2, 2009 at https://clinicaltrials.gov/search?term=NCT00970866. The trial in Bangladesh was registered as NCT01715038 on October 23, 2012 at...

BACKGROUND: Low Titer Group O Whole Blood (LTOWB) use has expanded to include patients with non-traumatic bleeding etiologies. While a large body of evidence supports a potential survival benefit of LTOWB in trauma patients, data demonstrating the safety and efficacy of LTOWB in non-trauma patients are lacking.

Neutrophils rapidly accumulate in the heart after myocardial infarction (MI), yet bone marrow granulopoiesis peaks later, suggesting an alternative early source. Here we show in male mice that the first wave of neutrophils recruited to the ischemic heart arises from the vascular marginated pool rather than newly generated cells in the bone marrow or spleen. Using hematopoietic stem cell ablation, flow cytometry and proteomic analyses, we find that early MI-induced neutrophilia displays hallmarks...

Achieving efficient and durable oxygen electrocatalysis in protonic ceramic cells (PCCs) demands precise control of defect chemistry and cation redox under steam. Here, we design a hierarchically engineered oxygen electrode comprising a three-dimensional, mesh-like PrNi(0).(7)Co(0).(3)O(3-δ) (PNC) scaffold conformally integrated with a vacancy-rich PrO(x) nanophase. This architecture extends the reactive zone while the PrO(x)-PNC interphase enables vacancy-mediated redox coupling between Pr and...