No abstract

Workflows and software tools for peptide mapping have been extensively optimized and simplified for widespread use. However, top-down and middle-down workflows, despite offering valuable proteoform information not obtainable by peptide mapping, remain demanding in terms of user expertise as well as instrument setup, data analysis, and result validation. Current software offerings have also not been tailored to address targeted protein characterization workflows, often necessitating multiple...

Utilization of a blood pump to aid in circulating a patient's blood, otherwise known as mechanical circulatory support, is an effective and often life-saving treatment for cardiac/pulmonary failure patients, yet adverse events remain a common complication often attributed to mechanical trauma inflicted on blood components. This work specifically focuses on erythrocyte-derived extracellular vesicles (ErEVs) as a marker of this mechanical trauma as they are elevated in patients with blood pumps...

CONCLUSIONS: Three-week RT for GBM reduces patient OOP costs by ∼5% compared with 6-week RT. Incorporating financial considerations into treatment discussions may help reduce the economic burden of GBM care and support shared decision-making.

INTRODUCTION: Gender differences in academic performance are well-documented, with men showing lower retention and graduation rates, the psychological mechanisms underlying these disparities remain unclear. While gender differences in academic performance are well-documented, traditional approaches have relied on gender identity as the primary explanatory variable, yet this framing may obscure more nuanced behavioral and ideological factors at play. This study examines how masculine ideology...