The fall armyworm, Spodoptera frugiperda, is a major global agricultural pest, known for its rapid evolution of insecticide resistance. Although host genetic adaptation contributes to this trait, the role of gut symbiont-mediated metabolic pathways in promoting resistance remains poorly understood. Here, we show that besides direct biodegradation, a generalist symbiont Enterococcus casseliflavus EMBL-3 indirectly promotes chlorantraniliprole resistance by compensating for tryptophan deficiency...

Among European Association of Zoos and Aquaria (EAZA) Ex-situ Programs (EEPs), both African and Asian elephant populations represent good models of the benefits of collective, unified action to contribute to the conservation of threatened species. However, the management of mature male elephants poses distinct challenges for both population sustainability and animal wellbeing. Identifying the goals and challenges of institutional members as they relate to male elephant management will inevitably...

CONCLUSIONS: The bioinformatics approach used in this study suggests that, in addition to physiological reasons, shorter D-helix, larger heme cavity in tilapia and yellowfin tuna, and greater solvent-accessible area in poultry contribute to increased oxidation in myoglobin from poultry and fish compared with myoglobin from livestock species.

Poly(ADP-ribose) polymerase 1 (PARP1) is a multifunctional protein involved in diverse cellular functions, notably DNA damage repair. Pharmacological inhibition of PARP1 has therapeutic benefits for various pathologies. Despite the increased use of PARP inhibitors, challenges persist in achieving PARP1 selectivity and effective blood-brain barrier (BBB) penetration. The development of a PARP1-specific positron emission tomography (PET) radioligand is crucial for understanding disease biology and...

The goal of this study was to determine if measures of healthspan, which have been shown to decline with age, are associated with and predict mortality. We measured voluntary running activity, spontaneous activity, and cognition in male and female C57BL/6 mice at 26- to 28-months of age followed by analysis of the survival of each mouse. Voluntary running activity was positively associated with age at death in both male and female mice; however, only 14 to 21% of the variance in lifespan was...