CONCLUSIONS: Biomarkers of impaired distal perfusion, anterior circulation borderzone infarct, and hypoperfusion mismatch were associated with increased risk of recurrent ischemic stroke. These findings support the use of perfusion imaging in ICAS as well as future trials investigating early reperfusion in high-risk patients with ICAS.

CONCLUSION: miRNAs, especially miR-21, demonstrate significant utility for diagnosis of GBM and for ruling out diagnosis in patients who do not have GBM. These findings support the further development of miRNA-based liquid biopsies for GBM diagnosis with emphasis on clinical validation and standardization of technique.

Since its discovery in 1958, the orthopox monkeypox virus, a cause for mpox, has remained endemic in the African continent. Recently, a major epidemiological change in mpox virology is causing a global emergence. This review focuses on the novel mpox clades and explores transmission methods which are critical for public health measures and infection prevention.

Regulated cell death (RCD) is a fundamental biological process essential for tissue homeostasis, and the elimination of damaged or malignant cells. In cancer, dysregulation of RCD is closely linked to tumor initiation, progression, therapeutic resistance, and remodeling of the tumor microenvironment (TME). In this review, we classify RCD in cancer into three broad groups. Classical cell death types include apoptosis, autophagy, necroptosis, and pyroptosis, which have well-established roles in...

CONCLUSIONS: This study suggests that, for similarly injured patients, massive transfusion, airway management, hemorrhage control via laparotomy, and other cardiac procedures performed at TTCs explain most of the observed survival benefit for patients treated at TTCs.