This review is intended for forensic toxicologists and cheminformaticians seeking an understanding of the past implementations and future directions of artificial intelligence (AI) and machine learning (ML) for high-resolution mass spectrometry (HRMS) data interrogation in forensic toxicology. It provides a comprehensive overview of the data processing steps required to generate valid ML inputs, including molecular representation, augmentation, tokenization, embedding, and spectral...

BACKGROUND: Cannabis use (CU) has increased since its legalization, and we are currently assessing its impact on various chronic conditions. The literature supports the anti-inflammatory and antifibrotic effects of cannabidiol in various liver diseases using in vivo and in vitro models. This study explored the role of CU in the outcome of hospitalized patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

The establishment of stringent identification criteria is essential for accurate reporting of toxicological drug testing, particularly in forensic settings involving medico-legal cases. Liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) is widely employed for its broad analyte coverage and high mass accuracy, yet limited published and validated identification criteria pose significant challenges for its use beyond presumptive screening in low case volume settings....

CONCLUSION: Our findings suggest that APP and PGAM5 interact under physiological conditions. In AD, the decreased cleavage of PGAM5 may impair mitophagy, contributing to the mitochondrial dysfunction seen in AD pathogenesis. Precise understanding of the interaction of APP with other proteins, like PGAM5 is critical to ensure the long-term safety of potential treatments like APP knockdown in AD patients.

The adaptation account suggests that the persistence of some traditional values in modern society is due to their enduring adaptive utility. We tested this hypothesis by examining the change of filial piety in two Confucian societies, China and Japan. By analyzing natural language data, Study 1 found that Chinese people's concern about and liking for filial piety have increased since 1979, with falling birth rate and rising elderly population as the Granger causes. By analyzing survey data from...