CONCLUSIONS: This scalable, medical assistant-coached digital program shows promising benefits, including greater reductions in pain interference and a long-term improvement in global symptom burden, despite no difference at the primary endpoint.

Pollution resulting from mining, industry, and agriculture has played an important role in shaping the evolution of diverse organisms. Heavy metal contamination is of particular concern due to the health effects for humans and cross-tolerance effects that may influence pesticide resistance. We used a replicated artificial selection approach to examine the response to copper selection in Drosophila melanogaster collected from a retired mine and active fruit orchard. We tracked shifts in...

Organic anion transporting polypeptide (OATP) 1B3 plays a clinically significant role in hepatic drug disposition. Lysine acetylation, a key post-translational modification, has not been investigated for OATP1B3. This study determined the lysine acetylation status of OATP1B3 by proteomics and assessed the impact of inhibition of lysine deacetylase (KDAC) 6, a major cytosolic KDAC, on OATP1B3 acetylation and transport function. Proteomics revealed 7 acetylation sites, including 5 with additional...

In 2007, the American Society for Apheresis (ASFA) published guidance for physician documentation related to oversight of therapeutic apheresis (TA). Due to 21st century changes in healthcare delivery, the ASFA Board of Directors (BOD) charged its Public Affairs and Advocacy Committee (PAAC) to coordinate a review and update of the guidance. PAAC members reviewed minutes from various ASFA committees' earlier deliberations and sought additional information from the medical and general literature...

Mid-infrared laser absorption spectroscopy measurements of acetaldehyde in the headspace of yeast cultures are reported. An interband cascade laser (ICL) with single-mode tuning between 1770.19 and 1770.35 cm^(-1) was used to excite specific rotational-vibrational modes of motion in the R-branch of the carbonyl stretch absorption band for acetaldehyde. Real-time acetaldehyde measurements of seven different yeast cell cultures showed the effects of sucrose feeding, malted barley extract feeding,...