There is evidence that amyloidogenic segments in SARS-COV-2 proteins can induce aggregation of α-synuclein (αS), the main component of brain-located amyloids whose presence is connected with Parkinson's Disease (PD). Using molecular dynamics simulations, we showed in earlier work that SARS-COV-2 protein fragments shift the ensemble of αS chains toward more aggregation-prone conformations. However, the mechanism by which these chains assemble into fibrils, the presumed neurotoxic agents in PD, is...

Background: Unmet type 1 diabetes (T1D) needs in rural communities require collaborative academic-community partnerships to develop and test novel health care strategies. Objectives: The purpose of this community-based participatory project was to (a) build a robust community-academic research partnership, (b) complete individual and community-level research capacity building, and (c) develop a rural T1D patient-centered research agenda. Methodology: We implemented a four-strategy stakeholder...

Residential greenness, a fundamental component of urban design, could contribute to the prevention of respiratory infections via several potential mechanisms. However, the health benefits of greenness on influenza epidemics in real world are not as clear. In this cross-sectional, associational study, a series of logistic models were constructed to assess the association between individual-level residential greenness exposure, measured by the normalized difference vegetation index (NDVI), and the...

Improving ruminant production efficiency is contingent on accurately measuring gas fluxes from individual animals in grazing and confined feeding environments The GreenFeed system (GFS) has been increasingly utilized by researchers to measure gas flux of ruminants in their production environment. However, there are wide inconsistencies in methodologies from laboratory-to-laboratory. The objective of this manuscript is to provide standardized recommendations for measuring individual animal gas...

CONCLUSIONS: Blood-based DNA methylation models may predict incident knee OA in healthy individuals using a small set of CpG sites. Further work should focus on evaluating the pathophysiological role of DNA methylation in incident OA.