CONCLUSION: These findings highlight a persistent mismatch between the evidence clinicians need and the trials currently conducted. To bridge this gap, future MH RCTs could broaden eligibility, publish de-identified data and economic analyses, and reflect positive patient outcomes. Strengthening these domains may accelerate translation of research into reliable and equitable MH care for the more than one billion people affected worldwide.

CONCLUSIONS: Minority stress experiences may impact SMYAs' concurrent and subsequent tobacco use. These daily minority stress experiences and tobacco use episodes occur more often and at higher levels among rural- (vs. urban-) residing SMYAs, highlighting the need for interventions focused on promoting adaptive coping in response to minority stressors in real time, particularly for rural-residing SMYAs.

The role of host cell-derived extracellular vesicles (EVs) in host-pathogen interactions remains to be defined during mycobacterial infection. In this study, we characterized EVs from mouse RAW 264.7 cells uninfected or infected with Mycobacterium abscessus (M.ab), one of the most common nontuberculous mycobacterial (NTM) pathogens in humans. Our results show that M.ab infection increased the release of EVs but had no effect on the size distribution and total protein abundance of EVs from RAW...

Data on effects of hemp (Cannabis sativa L.) variety and botanical part on ruminal nutrient disappearance are currently limited. Plants were harvested from 2 fiber- (CFX-2 and CRS-1) and 2 flower-based (Grandi and Katani) hemp varieties. Plants were separated into stems, leaves and seeds by variety. In situ disappearance of dry matter (DM), organic matter (OM), detergent fiber and crude protein (CP) was obtained by incubating bags containing unique combinations of variety and botanical part in 2...

Body size variation in vertebrates is a complex polygenic trait, tightly correlated with numerous aspects of a species' biology, ecology, and physiology. Miniaturization, the extreme reduction of adult body size, is a common phenomenon across the Tree of Life, yet the mechanisms underlying this process are poorly understood. Here, we investigate the molecular basis of body size evolution in goby fishes, a clade encompassing some of the smallest vertebrates on Earth. We generate a genome-wide...