CONCLUSIONS: Neonatal tele-resuscitation workshops improved providers' perceptions of this service and increased their acceptance of such a program. Additionally, the skill sessions and simulated resuscitations increased their confidence with procedures commonly performed during advanced neonatal resuscitation.

Understanding how abiotic conditions interact with species interactions to shape outcomes of secondary contact remains a central challenge in evolutionary biology. Environmental stress may limit persistence through physiological constraints, but it can also alter competitive dynamics, determining whether closely related species can coexist. We investigated these mechanisms in two long-studied secondary contact zones between the darter species Etheostoma pulchellum and E. radiosum spp. in...

CONCLUSIONS: Ovarian-derived signals induce metabolic reprogramming in aged mice, characterized by reduced β-oxidation protein expression, decreased triglyceride accumulation, and improved metabolic efficiency. These findings provide a molecular framework for understanding how ovarian-derived factors may govern metabolism and organismal health during aging, with potential implications for interventions targeting age-related metabolic decline.

We review the use of optimality in the investigation of the large-scale geometry of the DNA-protein complex of chromatin using a generalized information principle. Considering systems level optimality requires that not only should all sub-parts of a natural process be optimal, but this also be true for the unfolding of higher recursive levels that include symbolic abstractions. An information-theoretic geometry of the genetic code data, together with the principle of maximum entropy, explains...

CONCLUSIONS: Conclusions: This study is the first large-scale evaluation of at-home SC ketamine. Results suggest at-home SC ketamine is a safe, feasible intervention associated with high rates of symptom reduction in depression, anxiety, and PTSD. It differs from existing literature by utilizing a high-bioavailability (93%) SC route in a remote setting, whereas patients typically receive infusions of this potency in-clinic. Patients achieved clinical outcomes comparable to or exceeding...