CONCLUSIONS: Competencies developed will inform individual lectures/modules in a Core Curriculum for APPs in A&I, a steppingstone in education dedicated to the APP role in the field.

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BACKGROUND AND OBJECTIVES: Oral cladribine tablet (CladT) therapy is efficacious for relapsing multiple sclerosis (MS). However, the mechanisms by which cladribine exerts benefit in MS remain unclear, particularly regarding its effects on compartmentalized inflammation within the CSF.

CONCLUSION: Automated SC morphometry reveals key age-dependent and sex-dependent differences in DCM. Age-based and sex-based morphometrics offer anatomically specific and individualized biomarkers for risk stratification, progression monitoring, and surgical outcome prediction.

CONCLUSION: Six weeks of CBT-I resulted in significant and sustained reductions in insomnia severity in older adults. Baseline sleep self-efficacy and depression severity significantly predicted lower insomnia severity following CBT-I, whereas only sleep self-efficacy predicted the long-term maintenance of treatment gains. These findings underscore the importance of baseline sleep self-efficacy as key predictor for optimizing treatment planning and long-term outcomes.