ADLumin is a new class of turn-on chemiluminescent probes that have shown increased luminescent intensity in the presence of amyloid beta ( A β $$ \mathrm{A}\beta $$ ) plaques, which are commonly associated with Alzheimer's disease (AD). ADLumin shares an imidazopyrazinone (IPO) moiety with the well-known Cypridina luciferin, which reacts with O(2) and produces bioluminescence. While the reaction mechanism for many other luciferins has been studied extensively, the chemiluminescent mechanism...

Phosphorylated peptides presented by human leukocyte antigen (HLA) class II molecules play pivotal roles in immune regulation, yet their characterization and prediction remain challenging due to data noise and limited HLA coverage. Here, we introduce NetMHCIIphosPan, a prediction method for HLA-II antigen presentation of phosphorylated peptides, developed using mass spectrometry (MS)-based immunopeptidomics data sets. Employing a refined peptide identification workflow, we reanalyzed earlier...

Porokeratoma (PRKT) is a rare epidermal acanthoma that can clinically resemble other hyperkeratotic or verrucous lesions, creating potential diagnostic uncertainty without histopathologic evaluation. It typically presents as a solitary exophytic lesion that lacks the annular architecture associated with other porokeratosis variants and may therefore be misclassified on clinical examination alone. We report the case of an immunocompetent 67-year-old male with a 10-week history of a progressively...

CONCLUSION: Significant improvement in MELD-Na & Fibroscan scores were observed in patients on treatment with ETV.

Plastics are ubiquitous in all trophic environments. Human exposures primarily occur via ingestion, inhalation, and/or injection routes. However, laboratory models of micro- and nanoplastic (MNP) particle exposures replicating the human condition remain inconsistent and uncharacterized, thus limiting study strength and compromising the reliability of results. The purpose of this study was to thoroughly optimize and characterize an established methodology for MNP rodent inhalation exposures, and...