Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease in children and adolescents. Assessment of circulating biomarkers is needed to understand the underlying pathology, disease severity, and treatment options. The secreted hepatokine Tsukushi (TSK) is involved in lipid and carbohydrate metabolism. TSK is increased in adults with MASLD but has yet to be reported in adolescents. We hypothesized that plasma TSK is increased in adolescents with MASLD...

In Medicago littoralis R-108, Symbiotic CYSTEINE-RICH RECEPTOR-LIKE KINASE (MtSymCRK) is required to prevent defense reactions in symbiotic nodules during chronic infection. MtSymCRK represents a key legume symbiotic gene controlling nodule immunity and early bacteroid survival, but its mode of action in the cell signaling remains poorly understood. This study investigated proteins interacting with MtSymCRK by screening an Arabidopsis thaliana open reading frame (ORF) library using...

An initial comparison of 16S rRNA gene sequences between Alkalispirochaeta alkalica Z-7491^(T) and other members of the genus Alkalispirochaeta revealed ≥99.4% sequence similarity, suggesting their close relatedness and the possibility that some members are in fact the same species. The genus Alkalispirochaeta includes five species with validly published names. A. alkalica Z-7491^(T) (=ATCC 700262^(T)=DSM 8900^(T)) and Alkalispirochaeta sphaeroplastigenens JC133^(T) (=KCTC 15220^(T)=NBRC...

Two mesophilic, Gram-stain-positive bacteria, OSA5^(T) and AGF001^(T), were isolated anoxically from ostrich faecal material. Phylogenetic analyses based on 16S rRNA gene and whole-genome sequences revealed that strains OSA5^(T) and AGF001^(T) formed distinct lineages within the genera Luteococcus and Lacrimispora, respectively. Strain OSA5^(T) showed the closest relatedness to Luteococcus japonicus DSM 10546^(T) and Luteococcus sediminum DSMZ 27277^(T) with 96.6% 16S rRNA gene sequence...

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