CONCLUSIONS AND RELEVANCE: Symptom-based dosing decreased time to medical readiness for discharge compared with a scheduled opioid taper approach among infants cared for with ESC.

Biologics, such as monoclonal antibodies, therapeutic proteins, gene therapies, and vaccines, are revolutionizing treatments for cancer, autoimmune disorders, and infectious diseases. However, their inherent sensitivity to environmental factors like heat and moisture necessitates advanced stabilization techniques. Lyophilization, or freeze-drying, has emerged as a critical method to preserve biologics by removing water through sublimation, resulting in a stable, dry powder. This review examines...

CONCLUSIONS: Participants in both conditions reported significant improvements in primary and secondary outcomes at EOT and 1-month post-treatment, with no statistically significant difference in improvement between conditions.

Laboratory animals are critical to many scientific disciplines, and it is the responsibility of researchers and oversight bodies, such as Institutional Animal Care and Use Committees, to ensure their health and welfare. Positive health and welfare outcomes are typically achieved using planned and approved structural, chemical (e.g., pain relief) and environmental techniques. Despite these efforts, captive animals are still likely to experience unpredictable and/or acute disturbances due to human...

Top-down mass spectrometry (TDMS) is a powerful platform for the structural and functional analysis of intact proteins, enabling the detailed characterization of proteoforms and precise localization of post-translational modifications. The incorporation of alternative fragmentation techniques, such as electron transfer dissociation, electron transfer higher-energy collisional dissociation, and ultraviolet photodissociation, in instruments such as Tribrid Orbitrap mass spectrometers enhances...