BCL6, a transcription factor central to T follicular helper (TFH) cell differentiation, has recently been identified as a key regulator of T cell-mediated neuroinflammation. While previous research has established a connection between Th17 cells and B cell responses in autoimmune diseases, most notably in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis-the role of BCL6 in T cell subsets beyond TFH cells remains unclear. In this study, we explored the impact of T...

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Nitrogen-containing heterocycles (N-Hets) are among the most prevalent and versatile structural motifs in pharmaceuticals, serving as key scaffolds in over 85% of biologically active small molecules. Their structural diversity and functional versatility have made them integral components of both U.S. Food and Drug Administration (FDA) approved and investigational drug molecules, modulating biological activity across a range of molecular targets. In 2025, the FDA approved 26 small-molecule drugs...

CONCLUSIONS: Racial and ethnic disparities in T-TEER outcomes are evident, with Black patients experiencing higher major and overall complications, and Black and Hispanic patients having prolonged hospitalizations. Further investigation into the specific factors and policies driving these disparities is crucial in striving for more equitable cardiovascular care among different racial and ethnic populations.

Limited guidance exists for the management of methamphetamine-associated PAH (Meth-APAH) and the experiences of physicians treating this population are not well documented. This study explored how physicians approach diagnosis and treatment and identified unmet needs in clinical care through structured interviews with 30 U.S. pulmonologists and cardiologists who manage patients with Meth-APAH. Physicians relied heavily on patient self-report to establish methamphetamine use; only 20% performed...