No abstract

Heart transplantation continues to be the definitive treatment for end-stage heart failure, but organ availability limits access nationwide. Donation after circulatory death (DCD) hearts have shown tremendous promise as a viable avenue for expanding the donor pool. Still, the expanded utilization of DCD hearts has introduced new challenges that evaluating centers must work to address. Among these is the frequently variable and incomplete diagnostic information available on DCD donors before...

The neuropeptide neurotensin (NTS) is up-regulated in cardiac lymphatic endothelial cells (LECs) in response to ischemic or mechanical damage, but its role in cardiac remodeling is unknown. Here, we aimed to define the role of LEC-derived NTS in cardiac injury responses and to assess the therapeutic potential of targeting cardiac NTS signaling. In cultured murine and human cells, NTS reduced cardiomyocyte hypertrophy and fibroblast activation, and these effects were mediated by NTS receptor 2...

In this contribution, we report the synthesis of the diphosphane P(2)(C(2)F(5))(4) and cyclotetraphosphane (PC(2)F(5))(4) from the corresponding bromophosphanes P(C(2)F(5))(x)Br(3-) (x) (x = 1, 2). The molecular structure of the cyclotetraphosphane was determined by x-ray diffraction analysis. Subsequent reaction of P(2)(C(2)F(5))(4) with trimethylphosphane (PMe(3)) afforded the phosphanyl-functionalized phosphorus ylide (Wittig reagent) Me(3)P = C(CF(3))P(C(2)F(5))F, whereas treatment of...

Age-related decline in left ventricular (LV) diastolic function is a hallmark of cardiac aging and an early precursor to cardiovascular disease. While dyslipidemia is a known driver of coronary heart disease (CHD), the molecular pathways linking lipid metabolism to cardiac aging and subsequent CHD risk remain poorly understood. Furthermore, longitudinal lipidomic profiling of cardiac aging in large human populations has not been systematically conducted. Using an untargeted LC-MS, we repeatedly...