Virtual reality (VR) is increasingly being used as an innovative technology for assessment, treatment, and training within psychiatric settings. However, little work has been done to synthesize existing literature on the use and benefits of VR in forensic-correctional settings. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. Protocol is available at Open Science Framework (https://osf.io/3m6p2). A total of 1317...

This study explores the influence of experiencing one, two or more stressful life events (SLE) in the past year in associations with adolescent sleep and depression symptomatology in the short and long term in the context of coping. Participants were 2323 Hispanic (44.1%), non-Hispanic Black (30.5%), non-Hispanic White (8.6%), and non-Hispanic Asian (16.7%) eighth graders (51.1% female) from 24 public middle schools in southeast Texas in 2019. Multivariate linear and logistic regressions for the...

CONCLUSIONS: This formative pilot study will inform the cultural adaptation and refinement of an mHealth app, VITAL, which will be tested in a subsequent randomized controlled trial to improve health disparities and assist Hispanic people with HIV in quitting smoking.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by frequent KRAS mutations, which activate the MAPK pathway to promote PDAC progression. Here, we explored metabolic vulnerabilities of PDAC by assessing initial metabolic reprogramming upon ERK inhibition using metabolomics, lipidomics, and isotope-tracing experiments. ERK inhibition enhanced lipid turnover and fatty acid oxidation while inhibiting glycolysis, glucose oxidation, and glutamine metabolism in PDAC cells. Moreover, lipophagy,...

Myocardial fibrosis, steatosis, and heart failure with preserved ejection fraction are increasing among people with HIV (PWH). The sodium-glucose cotransporter type 2 inhibitor (SGLT2i) dapagliflozin has efficacy for cardiovascular disease (CVD) prevention in type 2 diabetes and is a promising therapy for the inflammatory component of CVD risk in PWH. We show dapagliflozin preserved diastolic function and suppressed cardiac fibrosis and steatosis linked to HIV in mice, suggesting potential...