Hereditary thrombotic thrombocytopenic purpura (hTTP) is a rare inherited blood disorder caused by severe ADAMTS13 deficiency due to biallelic ADAMTS13 mutations, leading to life-threatening complications across the life span. Its impact on long-term psychological, cognitive, and overall well-being remains poorly understood. This study evaluated patient-reported outcomes in individuals with hTTP, comparing them to the general US population and patients with other chronic conditions, and assessed...

CONCLUSIONS: Experience of discrimination appears to adversely impact smoking cessation among adults with socio-economic disadvantage who are trying to quit smoking and warrants attention in cessation interventions.

The importance of examining human papillomavirus (HPV) vaccine-related conspiratorial thinking and its effects has become more prominent amid the global increase in anti-vaccine activism. However, little is known about how conspiratorial thinking shapes vaccine-related outcomes and how these processes vary across sociocultural contexts. Using survey data from China (N = 619) and the United States (N = 600), this study distinguishes between conspiracy orientation and conspiracy attribution in the...

GWAS have identified multiple genetic regions that confer risk for juvenile idiopathic arthritis (JIA). However, identifying the single nucleotide polymorphisms (SNPs) that drive disease risk has been impeded by the fact that the SNPs used to identify risk loci are in linkage disequilibrium (LD) with hundreds of other SNPs. Since the causal SNPs remain unknown, it is difficult to identify target genes and thus use genetic information to elucidate disease biology and inform patient care. We next...

CONCLUSIONS AND RELEVANCE: In this cross-sectional study, otolaryngology surgeons experienced measurable increases in pain and sustained high rates of intraoperative ergonomic risk, even during routine procedures. Hand size was associated with greater intraoperative discomfort, underscoring the multifactorial nature of ergonomic strain during operations. These findings highlight the urgent need for increased ergonomic awareness, targeted training, and equipment redesign to mitigate risk and...