Currently, little is known about the exact role of Sarcocystis neurona immunopathology in equine protozoal myeloencephalitis (EPM), including the ability to persist after anti-protozoal treatment. The main objectives of this study were to determine whether S. neurona is present in the CNS in horses with EPM, including previously treated cases, and to evaluate the associated histopathology and immune response. For this study, control (n = 10) and horses with EPM (n = 9) were confirmed based on...

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Ultrasound-guided left-sided or bilateral stellate ganglion block (SGB) has emerged as an effective bedside intervention for malignant ventricular arrhythmias (VA) refractory to conventional therapies, with demonstrated safety and efficacy in multiple studies. We report a medically complex patient with presumed genotype-negative Long QT Syndrome (LQTS) who experienced a sudden, transient increase in arrhythmic events shortly after an uncomplicated left-sided ultrasound-guided SGB. To our...

In this study, we examined the effects of ibogaminalog (DM506), a nonhallucinogenic analog of ibogamine, in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN) induced by paclitaxel. We also assessed the effects of tabernanthalog (TBG) and investigated the potential role of serotonin receptor subtype 2A (5-HT(2A)R) for both compounds. DM506 and TBG demonstrated antinociceptive activity in the CIPN model. DM506 produced a more prolonged effect, lasting between 10 and 14 days, with...

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