Synthetic data generation is a promising approach for sharing data for secondary purposes in sensitive sectors. However, to meet ethical standards and legislative requirements, it is necessary to demonstrate that the privacy of the individuals upon which the synthetic records are based is adequately protected. Through an expert consensus process, we developed a framework for privacy evaluation in synthetic data. The most commonly used metrics measure similarity between real and synthetic data...

CONCLUSIONS: Flaps based on SEA perforators are versatile, reliable, and reproducible; thus, they represent a strong choice for chest and abdominal wall reconstructions.

BACKGROUND: Grouping streams into reference groups based on their similarities is a critical component of developing multi-metric indices to evaluate biotic integrity. The use of level III ecoregions is a common approach that has been successful for many geopolitical regions. However, the diversity in ecoregions across the state of Oklahoma results in excessive complexity in the application of reference groups. In this study, we sought to simplify Oklahoma's reference groups by considering the...

The anatomical basis of cerebrospinal and interstitial fluid clearance along the human ventral meninges remains poorly defined. Here, we present the in vivo and ex vivo evidence of a distinct CSF-ISF drainage compartment surrounding the middle meningeal artery (MMA) in humans. In five healthy participants, dynamic contrast-enhanced MRI revealed delayed signal enhancement along the MMA-peripheral region, peaking at 90 min, substantially later than adjacent vascular and lymphatic structures,...

Adipose tissue macrophages (ATMs) critically influence obesity-induced inflammation and metabolic dysfunction. Recent studies identified distinct ATM subsets characterized by markers such as CD11c, CD9, and Trem2, associated with pro-inflammatory and metabolically activated states. This protocol outlines a detailed, reproducible methodology for isolating, characterizing, and sorting these ATM subsets from murine epididymal white adipose tissue (eWAT) using multicolor flow cytometry. Key steps...