Stable isotope probing (SIP) traces the metabolism of biological cells using isotopically heavy substrates (e.g., ^(13)C, ^(15)N, or ²H). Confident identification of the metabolic products of isotopic labeling remains a challenge due to the difficulties in simulating, visualizing and annotating the isotopic patterns of partially labeled peptides and metabolites found in mass spectrometry (MS) data. Here, we present Aerith, an R package designed to visualize data of simulated and observed...

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CONCLUSION: Alterations in SMAD4 were predictive of treatment failure for patients receiving neoadjuvant FFX. These data warrant prospective evaluation and support future trial designs incorporating SMAD4 as a predictive genomic biomarker.

Metal porphyrins act as the reactive center of the ubiquitous monooxygenase, cytochrome P-450. As such, both their native and functionalized forms have been successfully utilized in studying biodegradation of a plethora of molecular substrates. Ionic liquids, although quite promising and possessing benign physicochemical properties, are poorly understood in terms of their biodegradability from a theoretical standpoint. In this article, a quantum mechanical treatment of ionic liquids...

Community resilience and stability have often been considered outcomes of interaction network structure. These assumptions have faced strong criticism, given implicit biases in metrics used and a lack of integration with ecological outcomes, leading to the overinterpretation of network properties. Within pollination networks, there is a need to integrate knowledge of network structure with estimates of pollination success that reflect the full complexity of this process. Here, we evaluated the...