We present systematic experimental studies of the impact of subwavelength structural geometries and electromagnetic field polarization on the resonance behavior of metallic metasurfaces at D-band frequencies. The measured influence of the photoconductive receiver antenna design in terahertz time-domain spectroscopy on the frequency-domain spectral features was analyzed. Numerical simulations reveal distinct resonance characteristics in the D-band regime, where extraordinary amplitude...

CONCLUSION: Frail patients have a three-times higher 30-day complication risk following proximal humerus surgery. rTSA is associated with higher rates of complications compared with internal fixation, but has steadily narrowed the gap over time. While the long-term outcomes and functional benefit should be considered, preoperative frailty assessment can be predictive of perioperative complications and disposition in this population.

Cystine/cysteine is critical for antioxidant response and sulfur metabolism in cancer cells and is one of the most depleted amino acids in the microenvironment of pancreatic ductal adenocarcinoma (PDAC). The effects of cystine limitation stress (CLS) on PDAC progression are poorly understood. Here we report that adaptation to CLS (CLSA) promotes PDAC cell proliferation and tumor growth through translational upregulation of the oxidative pentose phosphate pathway (OxPPP). OxPPP activates the de...

Cancer remains the leading cause of mortality worldwide. Radiotherapy (RT), a cornerstone of oncological treatment for over a century, has achieved great success in various cancers. However, radioresistance remains the primary factor leading to the failure of radiotherapy. Histone modifications in cancer cells are known to play a pivotal role in regulating radiosensitivity by modulating chromatin structure, either by loosening or tightening it. Here, we provide a comprehensive summary of the...

Monoacylglycerol lipase (MAGL) constitutes a crucial serine hydrolase within the endocannabinoid system, which has been suggested as a potential therapeutic target for the treatment of various neurodegenerative disorders. While MAGL inhibitors have entered the clinical arena, a highly selective and MAGL-specific positron emission tomography (PET) ligand holds promise to significantly facilitate clinical drug development by allowing the quantification of MAGL levels and the assessment of target...