Atherosclerosis is a lipid disorder where modified lipids (especially oxidized LDL) induce macrophage foam cell formation in the aorta. Its pathogenesis involves a continuum of persistent inflammation accompanied by dysregulated anti-inflammatory responses. Changes in the immune cell status due to differences in the lesional microenvironment are crucial in terms of plaque development, its progression, and plaque rupture. Ly6C^(hi) monocytes generated through both medullary and extramedullary...

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Flash droughts are rapidly intensifying drought events that can have severe impacts on both natural and human systems. This study assesses the vulnerability and resilience of different land use and land cover (LULC) types to flash droughts in the Mississippi River Basin (MRB) from 2000 to 2022. Using the Standardized Antecedent Precipitation Evapotranspiration Index (SAPEI) to identify flash drought events and Gross Primary Productivity (GPP) data to define recovery periods, 315 unique flash...

The pathology of cardiovascular aging is complex, involving mitochondrial dysfunction, oxidative and nitrative stress, oxidative DNA injury, impaired lipid metabolism, cell death, senescence, and chronic inflammation. These processes lead to remodeling and structural changes in the cardiovascular system, resulting in a progressive decline in cardiovascular reserve capacity and health, and an increased risk of diseases and mortality. Excessive alcohol consumption exacerbates these risks by...

CONCLUSIONS: Our study demonstrates a reduction in healthcare utilization and provides critical information to fix the significant, national burden that ED super-utilizers impose on the healthcare system. This program aligns well with the osteopathic principles of the whole-person approach, emphasizing prevention and wellness and prioritizing dignity in healthcare.