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the Gateway to Research in Oklahoma

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Gateway to Research in Oklahoma


Oklahoma Shared Clinical and Translational Resources U54 GM104938

Researchers

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The GRO: Researcher Portal provides resources, information, and training to help individuals or communities involved in performing clinical and translational research in Oklahoma.

Providers

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The GRO: Provider Portal assists medical providers to identify clinical research opportunities in Oklahoma, tools for patient education, and evidence-based resources to improve patient care.

Patients

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The GRO: Patient Portal can help patients and families to learn more about clinical and translational research and to connect with opportunities to participate in research opportunities in your communities.

Oklahoma Research Highlights

Bleaching efficacy and reduction of cytotoxicity of 6% H₂O₂ in-office bleaching gels formulated with hyaluronic acid, NF_TiO₂ nanoparticles, and violet LED irradiation: in vitro study

3 months ago
The objective is to evaluate the bleaching efficacy and cytotoxicity of innovative low-concentration in-office gels containing 6% hydrogen peroxide (H₂O₂), hyaluronic acid (HA), or carbomer 940 (CAR) as thickeners, titanium dioxide nanoparticles co-doped with nitrogen and fluorine (NF_TiO₂) and irradiated with violet LED. Bovine enamel/dentin disks adapted to artificial pulp chambers were randomly assigned to seven groups (n = 8): NC (negative control), HP35 (commercial control), HA, HA-HP6 +...
Priscila Borges Gobbo de Melo

Domain-Specific Physical Activity and Obesity Risk among Black Men in the United States: Evidence of a Physical Activity Paradox

3 months ago
Black American men in the United States face a disproportionate burden of obesity-related morbidity and mortality, which contributes to lower life expectancy. Although national guidelines suggest that physical activity regardless of domain can reduce obesity risk, emerging research on the "physical activity paradox" questions whether occupational physical activity (OPA) confers the same health benefits as leisure-time physical activity (LTPA). This paradox is especially relevant to Black...
Ailton Coleman

Broad-Spectrum Naphthyl-Substituted Diaminoquinolines Inhibiting the AdeG Efflux Pump of <em>Acinetobacter baumannii</em>

3 months ago
AdeFGH and AdeIJK, the two homologous multidrug efflux pumps of the resistance-nodulation-division superfamily of transporters, play distinct roles in Acinetobacter baumannii physiology and antibiotic resistance. Unlike ubiquitous AdeIJK, AdeFGH is strain-specific, typically expressed at low levels, and if overproduced, it enables resistance to a narrow spectrum of antibiotics, e.g., fluoroquinolones or chloramphenicol. In this study, we report that representatives of naphthyl-substituted...
Rushikesh Tambat

Social Determinants of Health and Pediatric Long COVID in the US

3 months ago
CONCLUSIONS AND RELEVANCE: In this study, economic instability that included food insecurity and poor social and community context were associated with greater odds of pediatric long COVID. Those with food security, despite experiencing other economic challenges, did not have greater odds of long COVID. Further study is needed to determine if addressing SDOH factors can decrease the rate of pediatric long COVID.
Kyung E Rhee

Electrolyte-Dependent, "Microscopically Irreversible" H-Atom Transfer Kinetics of Ce-Based Metal-Organic Framework, Ce-MOF-808

3 months ago
Redox reactions at the interface of metal oxides and protic electrolytes almost always involve protons and electrons in equal amounts. Given the stoichiometry, these proton-coupled electron transfer (PCET) reactions are thermochemically equivalent to net H-atom transfer (HAT) reactions. The correlation between the chemical nature of solid catalysts and HAT kinetics has been employed for decades as the design principle for energy-relevant reactions (e.g., reactions of 2H^(+)/H(2)). More recently,...
Miguel A Liuzzi-Vaamonde

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