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CONCLUSIONS: The novel epigenetic mechanism of action of forvisirvat, favorable safety profile, and consistent post-hoc efficacy results in women observed in this study support further development of forvisirvat. A phase 2b/3 trial of forvisirvat in major depressive disorder (NCT06254612), to confirm these results, is ongoing.

CONCLUSION: L-ALIF at L4-5 is a safe alternative to LLIF in L-SPS. Additionally, L4-5 L-ALIF enables more accurate restoration of L4-S1 lordosis and effectively improves L4-5 segmental lordosis.

Unplanned power outages create major economic costs. To better predict and manage these events, we present a multilayer graph neural network (GNN) framework that captures spatial, short-term co-occurrence, and statistically enriched co-failure patterns using 7 years of Oklahoma Gas & Electric data from 347 substations. These relations are encoded with weighted graph convolutions and fused by attention into a unified representation. For predictive maintenance, the model flags substations...