Drimane sesquiterpenoids are biologically active compounds found in plants, fungi, and marine organisms. Three isodrimenine derivatives, 5,6-dehydro-7-keto-isodrimenine (DH7KID), 7-keto-isodrimenine (7KID), and 7-acetoxy-isodrimenine (7AID), belonging to the drimane-type sesquiterpene family were synthesized and evaluated for activity at various human nicotinic acetylcholine receptor (nAChR) subtypes using two-electrode voltage-clamp electrophysiology. All three compounds exhibited comparable...

Hydrogen (H(2)) will play a part in decarbonizing the global energy system¹. However, hydrogen interacts with methane, ozone, and stratospheric water vapour, leading to an indirect 100-year global warming potential of 11 ± 4 (refs. ^(2-5)). This raises concerns about the climate consequences of increasing H(2) use under future hydrogen economies^(3,5). A comprehensive accounting of H(2) sources and sinks is essential for assessing changes and mitigating environmental risks. Here we analyse...

CONCLUSIONS: This cross-platform typology building supports digital health research by integrating AI and qualitative methods to categorize tobacco-related misinformation. It can inform the development of automated misinformation detection models, enhance real-time infodemiological monitoring, and guide digital public health campaigns to build tailored countermessaging.

Accurate interpretation of lab results is crucial in clinical medicine, yet most patient portals use universal normal ranges, ignoring conditional factors like age and gender. This study introduces Lab-AI, an interactive system that offers personalized normal ranges using retrieval-augmented generation (RAG) from credible health sources. Lab-AI has two modules: factor retrieval and normal range retrieval. We tested these on 122 lab tests: 40 with conditional factors and 82 without. For tests...

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