Aging is an inevitable process that is characterized by physiological deterioration and increased vulnerability to stressors. Therefore, the interest in hallmarks, mechanisms, and ways to delay or prevent aging has grown for decades. Natural plant products and their bioactive compounds have been studied as a promising strategy to overcome aging. Ginseng, a traditional herbal medicine, and its bioactive compound, the ginsenosides, have increasingly gained attention because of various...

T-cell receptor (TCR) T-cell therapies are adoptive cell therapies in which patient cells are engineered to express TCRs targeting specific cancer antigens and infused back into the patient. Since TCR recognition depends on antigen presentation by the human leukocyte antigen system, TCRs can respond to intracellular antigens. Cancer/testis antigens (CTAs) are a large family of proteins, many of which are only expressed in cancerous tissue and immune-privileged germline sites. Melanoma-associated...

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The principles of circular economy encourage the recovery of phosphorus from nutrient-rich waste streams such as animal manure, domestic wastewater, and urine to supplement existing sources of raw phosphorus. However, these waste streams also contain a wide variety of contaminants of emerging concern including antibiotics, and the recovery of phosphorus from these waste streams results in the co-occurrence of antibiotics with the recovered phosphorus products. This paper provides a comprehensive...

CONCLUSIONS: Our screening and predictive analysis of pathogenic missense variants in CTRP6 advance the understanding of the functional implications of these mutations, potentially facilitating more focused and efficient research in the future.