We present the case of a 13-month-old girl with Down syndrome who underwent probing to alleviate nasolacrimal duct obstruction (NLDO). During the procedure, a distal portion of the deployed Crawford hook fragmented and became lodged in the right nasopharynx. Traditional intraoperative methods of visualization were unsuccessful; however, extraction of the fragment was achieved by using a nasogastric bridle magnet. This case demonstrates a novel method of metallic foreign body removal, which may...

No theragnostic biomarkers exist for systemic lupus erythematosus (SLE) to enable a precision medicine approach. Baseline serum IgA2 anti-double-stranded DNA (dsDNA) antibody levels are associated with response to combination belimumab after rituximab therapy in SLE (BEAT-lupus trial, ISRCTN 47873003). Analysis of the CALIBRATE trial (NCT02260934) confirms that baseline IgA2 anti-dsDNA antibody levels are specifically associated with response to belimumab after rituximab (odds ratio [OR] = 16.9,...

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As empowering leadership becomes increasingly needed in today's complex organizations, so does the need to understand what motivates leaders to give more (or less) empowering leadership to followers. We draw on threat rigidity theory to examine how followers' challenging and supportive voice differentially impact the extent to which leaders empower their followers. We argue that leaders perceive followers' challenging voice as more threatening and tend to empower them less, whereas leaders...

CONCLUSION: T2 immune responses were associated with lower virus loads and more favorable clinical outcomes, suggesting that T2 inflammation related to asthma and allergic diseases may have a direct protective effect against SARS-CoV-2.