Background/Objectives: Metal transporter gene SLC39A8 and single nucleotide polymorphism (SNP) rs13107325 are associated with risk factors for atherosclerosis and cardiovascular disease (CVD). However, it is unclear how dietary manganese intake impacts CVD risk factors. The aim of this study was to use the UK Biobank population cohort (276,436 participants, Caucasian genetic ancestry, no genetic kinship) to investigate whether rs13107325 and dietary manganese are associated with CVD risk....

BECLIN-1 is a multidomain protein that, through dynamic interaction with a variety of partners, controls autophagy and apoptosis, two processes dysregulated in cancer cells, thus playing a crucial role in cell fate. Although mutations in the BECN1 gene are rare in cancer, its frequent monoallelic deletion contributes to spontaneous cancer initiation by impairing autophagy, establishing it as a haploinsufficient tumor suppressor gene. The expression and activity of BECLIN-1 are further modulated...

Background: Although most amputations caused by diabetes and peripheral artery disease (PAD) are preventable, current limb preservation efforts in the United States remain poorly understood. This study aims to identify key barriers and facilitators to limb preservation from the primary care provider (PCP) perspective. We plan to use the insights from this work to promote targeted intervention strategies. Methods: Using a mixed-methods design, an online 5-10 min survey was distributed to Oklahoma...

The micro-interface slip damping mechanism is insensitive to temperature, making it suitable for applications where the operating environment makes viscoelastic polymers ineffective. Damping material systems that rely on micro-interface slip typically embody randomly disposed interlocking units leading to complex material behaviors. This work studies a compressed coir vibration isolator that provides a lightweight, low cost and environmentally friendly alternative to common polymer devices....

CONCLUSION: Chemotherapy use has evolved for older adults with mPDAC and varies across levels of baseline frailty. The heterogeneity in chemotherapy selection and practice patterns in older adults merits ongoing investigation to help ensure patients receive treatment tailored to their unique geriatric needs.