As droughts become longer and more intense, impacts on terrestrial primary productivity are expected to increase progressively. Yet, some ecosystems appear to acclimate to multiyear drought, with constant or diminishing reductions in productivity as drought duration increases. We quantified the combined effects of drought duration and intensity on aboveground productivity in 74 grasslands and shrublands distributed globally. Ecosystem acclimation with multiyear drought was observed overall,...

Endovascular thrombectomy (EVT) is an established treatment for acute ischemic stroke, due to large vessel occlusion (LVO), but the optimal time window for intervention remains a subject of ongoing debate. We aimed to assess the impact of treatment timing on mortality, functional outcomes, and safety by comparing early (≤ 6 h) versus late (> 6-24 h) EVT. We conducted a systematic review and meta-analysis to evaluate the effect of time to intervention on outcomes of endovascular thrombectomy...

CONCLUSION: A 45-min downhill walking exercise at a - 10% slope represents a valid strategy to stimulate the cardiovascular and muscular functions, as inferred from the increase in MSTN and IL-6 exerkines levels, and the use of a steepest slope protocol is no a prerequisite to elicit greater responses.

CONCLUSIONS: The study identifies novel associations between surfactant protein gene SNPs and ROP risk that may impact protein structure, function in the retinal vasculature.

Adopted by 193 countries in 2015, the United Nations' 17 Sustainable Development Goals (SDGs) aim to address urgent global challenges by 2030. However, consistent and comprehensive assessments of countries' spatiotemporal performance, and of the balance and coordination among the SDGs, remain scarce. Here, we developed three indices-the Sustainable Development Relative Performance Index (SDRPI), Sustainable Development Gini Index (SDGI), and Sustainable Development Coordination Index (SDCI)-to...