SUMMARYIn fungi, the endomembrane system is a pleiomorphic, dynamic network of organelles, driven by vesicle trafficking pathways, which maintain cellular homeostasis, hyphal polar growth, and the secretion of proteins and metabolites. In syncytial hyphae, spatial specialization of organelles and other cellular components of the endomembrane system is evident to support growth and adaptation. Young, apical regions of hyphae contain a Golgi-Spitzenkörper-exocyst triad for rapid polar expansion,...

Mass spectrometry (MS)-based top-down proteomics (TDP) has emerged as a powerful tool for characterizing proteoforms to advance both fundamental and translational research. TDP requires high-efficiency liquid-phase separation, high-resolution MS, and tandem MS. Capillary zone electrophoresis (CZE)-MS has been proposed as a promising analytical technique for protein analysis decades ago because of its unique and valuable features, including high separation efficiency and high detection...

CONCLUSION: This study shows the feasibility and cost-effectiveness of free skin screenings when paired with local farmers' markets, which often provide complimentary spaces for nonprofit organizations. These low-cost models may enhance earlier detection and awareness in communities with limited access.

CONCLUSIONS: SRs informing LBP CPGs show variable reporting and methodological quality with consistent shortfalls in protocol registration, exclusion justifications, and publication-bias assessment. Cochrane SRs outperformed non-Cochrane SRs yet comprised only a minority of the evidence base. Facilitating uptake of protocol registration, complete PRISMA-aligned reporting, transparent exclusion lists, and routine small-study bias assessment, alongside greater use of methodologically stronger SRs,...

While Indigenous communities have thrived for centuries despite colonization, Indigenous Peoples continue to experience high rates of sexual victimization and are rarely included in sexual assault prevention and intervention research. Given the common risk factors associated with experiencing sexual assault, including substance use, it is vital to understand the unique strengths and challenges of Indigenous young adults to inform prevention and intervention efforts. The goal of this study was to...